Effects of 5-hydroxytryptamine and ergotamine on human superficial temporal artery

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  • The Department of Neurosurgery
  • The Department of Paediatrics
Isometric tension was recorded in ring preparations of human superficial temporal arteries contracted by noradrenaline (NA), 5-hydroxytryptamine (5-HT), and ergotamine. In contrast to NA and 5-HT, ergotamine induced long-lasting contractions refractive to additional stimulations and resistant to repeated wash-out. When tested against 5-HT, ergotamine acted as a non-competitive antagonist. When repeating the 5-HT stimulations (4.7 x 10(-5) M) the contractile response decreased indicating tachyphylaxis to this agent. As ergotamine revealed both a vasoconstrictive and a 5-HT-blocking activity, the beneficial effect in migraine may be by an interference during both the vasoconstrictory and vasodilatory phases.
Original languageEnglish
JournalCephalalgia
Volume1
Issue4
Pages (from-to)223-8
Number of pages5
ISSN0333-1024
Publication statusPublished - 1981

    Research areas

  • Adult, Aged, Dose-Response Relationship, Drug, Ergotamine, Female, Humans, Male, Middle Aged, Migraine Disorders, Muscle Contraction, Muscle, Smooth, Vascular, Norepinephrine, Serotonin, Serotonin Antagonists, Tachyphylaxis, Temporal Arteries, Vasoconstriction

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