Effect of tranexamic acid on markers of inflammation in children undergoing craniofacial surgery

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Effect of tranexamic acid on markers of inflammation in children undergoing craniofacial surgery. / Fenger-Eriksen, Christian; Rasmussen, Mads; Juul, Niels; Krog, Jan; Hvas, Anne Mette.

In: Acta Anaesthesiologica Scandinavica, Vol. 65, No. 1, 01.2021, p. 34-39.

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@article{91f333a8ebf647d18cca4f562695c3fc,
title = "Effect of tranexamic acid on markers of inflammation in children undergoing craniofacial surgery",
abstract = "Background: Tranexamic acid (TXA) reduces blood loss and transfusion requirements during craniosynostosis surgery in small children. Possible interaction from TXA on the inflammatory system is unknown. Objective: To evaluate the effect of TXA on a wide range of inflammatory markers in children receiving TXA in a randomized, blinded, and placebo controlled study design. Methods: Thirty children undergoing craniosynostosis surgery with significant blood loss received TXA (bolus dose of 10 mg kg−1 followed by 8 hours continuous infusion of 3 mg kg−1 h−1) or placebo in a randomized, double-blinded study design. Using a new proximity extension assays employing a panel of inflammatory biomarkers samples was used for analysis of blood samples obtained pre-operatively, 4 and 24 hours after operation. Results: Ninety-two inflammatory parameters were measured. TXA did not affect any of the measured parameters as compared with placebo. Among 34 of the 92 pro- and antiinflammatory parameters investigated changes were observed between pre-operative, 4 or 24 hours, respectively, reflecting immune activation during surgical stress. Conclusion: TXA administration in a low-dose regimen including bolus followed by 8 hours infusion during craniosynostosis surgery did not change any of 92 inflammatory markers as compared with placebo.",
keywords = "antifibrinolytic agents, craniosynostoses, fibrinolysis, haemorrhage, inflammation",
author = "Christian Fenger-Eriksen and Mads Rasmussen and Niels Juul and Jan Krog and Hvas, {Anne Mette}",
year = "2021",
month = jan,
doi = "10.1111/aas.13700",
language = "English",
volume = "65",
pages = "34--39",
journal = "Acta Anaesthesiologica Scandinavica",
issn = "0001-5172",
publisher = "Wiley-Blackwell Publishing, Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Effect of tranexamic acid on markers of inflammation in children undergoing craniofacial surgery

AU - Fenger-Eriksen, Christian

AU - Rasmussen, Mads

AU - Juul, Niels

AU - Krog, Jan

AU - Hvas, Anne Mette

PY - 2021/1

Y1 - 2021/1

N2 - Background: Tranexamic acid (TXA) reduces blood loss and transfusion requirements during craniosynostosis surgery in small children. Possible interaction from TXA on the inflammatory system is unknown. Objective: To evaluate the effect of TXA on a wide range of inflammatory markers in children receiving TXA in a randomized, blinded, and placebo controlled study design. Methods: Thirty children undergoing craniosynostosis surgery with significant blood loss received TXA (bolus dose of 10 mg kg−1 followed by 8 hours continuous infusion of 3 mg kg−1 h−1) or placebo in a randomized, double-blinded study design. Using a new proximity extension assays employing a panel of inflammatory biomarkers samples was used for analysis of blood samples obtained pre-operatively, 4 and 24 hours after operation. Results: Ninety-two inflammatory parameters were measured. TXA did not affect any of the measured parameters as compared with placebo. Among 34 of the 92 pro- and antiinflammatory parameters investigated changes were observed between pre-operative, 4 or 24 hours, respectively, reflecting immune activation during surgical stress. Conclusion: TXA administration in a low-dose regimen including bolus followed by 8 hours infusion during craniosynostosis surgery did not change any of 92 inflammatory markers as compared with placebo.

AB - Background: Tranexamic acid (TXA) reduces blood loss and transfusion requirements during craniosynostosis surgery in small children. Possible interaction from TXA on the inflammatory system is unknown. Objective: To evaluate the effect of TXA on a wide range of inflammatory markers in children receiving TXA in a randomized, blinded, and placebo controlled study design. Methods: Thirty children undergoing craniosynostosis surgery with significant blood loss received TXA (bolus dose of 10 mg kg−1 followed by 8 hours continuous infusion of 3 mg kg−1 h−1) or placebo in a randomized, double-blinded study design. Using a new proximity extension assays employing a panel of inflammatory biomarkers samples was used for analysis of blood samples obtained pre-operatively, 4 and 24 hours after operation. Results: Ninety-two inflammatory parameters were measured. TXA did not affect any of the measured parameters as compared with placebo. Among 34 of the 92 pro- and antiinflammatory parameters investigated changes were observed between pre-operative, 4 or 24 hours, respectively, reflecting immune activation during surgical stress. Conclusion: TXA administration in a low-dose regimen including bolus followed by 8 hours infusion during craniosynostosis surgery did not change any of 92 inflammatory markers as compared with placebo.

KW - antifibrinolytic agents

KW - craniosynostoses

KW - fibrinolysis

KW - haemorrhage

KW - inflammation

UR - http://www.scopus.com/inward/record.url?scp=85091614792&partnerID=8YFLogxK

U2 - 10.1111/aas.13700

DO - 10.1111/aas.13700

M3 - Journal article

C2 - 32905611

AN - SCOPUS:85091614792

VL - 65

SP - 34

EP - 39

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

IS - 1

ER -