Effect of resistance exercise contraction mode and protein supplementation on members of the STARS signaling pathway

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The striated muscle activator of Rho signaling (STARS) pathway is suggested to provide a link between external stress responses and transcriptional regulation in muscle. However, the sensitivity of STARS signaling to different mechanical stress has not been investigated. In a comparative study, we examined the regulation of the STARS signaling pathway in response to unilateral resistance exercise performed as either eccentric (ECC) or concentric (CONC) contractions as well as prolonged training; with and without whey protein supplementation. Skeletal muscle STARS, myocardian-related transcription factor-A (MRTF-A) and serum response factor (SRF) mRNA and protein, as well as muscle cross sectional area and maximal voluntary contraction were measured. A single-bout of exercise produced increases in STARS and SRF mRNA and decreases in MRTF-A mRNA with both ECC and CONC exercise, however with an enhanced response occurring following ECC exercise. A 31% increase in STARS protein was observed exclusively after CONC exercise (p
Original languageEnglish
JournalThe Journal of Physiology
Pages (from-to)3749-3763
Publication statusPublished - 1 Aug 2013

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