TY - JOUR
T1 - Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients
T2 - The CONDI-2 echocardiographic sub-study
AU - Wood, Gregory
AU - Johnsen, Pia Hedegaard
AU - Pedersen, Anders Lehmann Dahl
AU - Frederiksen, Christian Alcaraz
AU - Poulsen, Steen Hvitfeldt
AU - Bøtker, Hans Erik
AU - Kim, Won Yong
N1 - Copyright © 2023 Wood, Johnsen, Pedersen, Frederiksen, Poulsen, Bøtker and Kim.
PY - 2023/1/25
Y1 - 2023/1/25
N2 - Background: Remote ischaemic conditioning (RIC) applied to the arm by inflation and deflation of a pneumatic cuff has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (PPCI). However, the effect of RIC on left ventricular ejection fraction (LVEF) following infarct healing remains unknown. Objective: To investigate whether RIC applied in the ambulance before PPCI can improve left ventricular (LV) function in STEMI patients 3 months following infarction. Methods: Echocardiography was performed in a total of 694 patients from the CONDI-2 study a median of 112 days (IQR 63) after the initial admission. LVEF and LV end-diastolic and end-systolic volumes were calculated using the modified Simpsons biplane method of disks. LV global longitudinal strain (GLS) was estimated using 2-dimensional cine-loops with a frame rate > 55 frames/second, measured in the three standard apical views. Results: There was no difference in the measured echocardiographic parameters in the RIC group as compared to the control group, including LV EF, LV GLS, tricuspid annular plane systolic excursion or left ventricular volumes. In the control group, 32% had an ejection fraction < 50% compared to 37% in the RIC group (p = 0.129). Conclusion: In this largest to date randomized imaging study of RIC, RIC as an adjunct to PPCI was not associated with a change in echocardiographic measures of cardiac function compared to standard PPCI alone.
AB - Background: Remote ischaemic conditioning (RIC) applied to the arm by inflation and deflation of a pneumatic cuff has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (PPCI). However, the effect of RIC on left ventricular ejection fraction (LVEF) following infarct healing remains unknown. Objective: To investigate whether RIC applied in the ambulance before PPCI can improve left ventricular (LV) function in STEMI patients 3 months following infarction. Methods: Echocardiography was performed in a total of 694 patients from the CONDI-2 study a median of 112 days (IQR 63) after the initial admission. LVEF and LV end-diastolic and end-systolic volumes were calculated using the modified Simpsons biplane method of disks. LV global longitudinal strain (GLS) was estimated using 2-dimensional cine-loops with a frame rate > 55 frames/second, measured in the three standard apical views. Results: There was no difference in the measured echocardiographic parameters in the RIC group as compared to the control group, including LV EF, LV GLS, tricuspid annular plane systolic excursion or left ventricular volumes. In the control group, 32% had an ejection fraction < 50% compared to 37% in the RIC group (p = 0.129). Conclusion: In this largest to date randomized imaging study of RIC, RIC as an adjunct to PPCI was not associated with a change in echocardiographic measures of cardiac function compared to standard PPCI alone.
KW - CONDI-2/ERIC-PPCI
KW - ST-elevation myocardial infarction
KW - echocardiography
KW - left ventricular function
KW - remote ischaemic conditioning
UR - http://www.scopus.com/inward/record.url?scp=85147649505&partnerID=8YFLogxK
U2 - 10.3389/fcvm.2022.1054142
DO - 10.3389/fcvm.2022.1054142
M3 - Journal article
C2 - 36762305
SN - 2297-055X
VL - 9
SP - 1054142
JO - Frontiers in Cardiovascular Medicine
JF - Frontiers in Cardiovascular Medicine
M1 - 1054142
ER -