Effect of Genetic Polymorphisms on Pain Sensitivity in the Orofacial Region: A Systematic Review

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

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Effect of Genetic Polymorphisms on Pain Sensitivity in the Orofacial Region : A Systematic Review. / Carvalho Soares, Flávia Fonseca; Poluha, Rodrigo Lorenzi; De la Torre Canales, Giancarlo; Costa, Yuri Martins; Nascimento, Gustavo G; Rodrigues Conti, Paulo César; Bonjardim, Leonardo Rigoldi.

In: Journal of Oral & Facial Pain and Headache, Vol. 34, No. 4, 12.2020, p. 353-363B.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Harvard

Carvalho Soares, FF, Poluha, RL, De la Torre Canales, G, Costa, YM, Nascimento, GG, Rodrigues Conti, PC & Bonjardim, LR 2020, 'Effect of Genetic Polymorphisms on Pain Sensitivity in the Orofacial Region: A Systematic Review', Journal of Oral & Facial Pain and Headache, vol. 34, no. 4, pp. 353-363B. https://doi.org/10.11607/ofph.2641

APA

Carvalho Soares, F. F., Poluha, R. L., De la Torre Canales, G., Costa, Y. M., Nascimento, G. G., Rodrigues Conti, P. C., & Bonjardim, L. R. (2020). Effect of Genetic Polymorphisms on Pain Sensitivity in the Orofacial Region: A Systematic Review. Journal of Oral & Facial Pain and Headache, 34(4), 353-363B. https://doi.org/10.11607/ofph.2641

CBE

Carvalho Soares FF, Poluha RL, De la Torre Canales G, Costa YM, Nascimento GG, Rodrigues Conti PC, Bonjardim LR. 2020. Effect of Genetic Polymorphisms on Pain Sensitivity in the Orofacial Region: A Systematic Review. Journal of Oral & Facial Pain and Headache. 34(4):353-363B. https://doi.org/10.11607/ofph.2641

MLA

Carvalho Soares, Flávia Fonseca et al. "Effect of Genetic Polymorphisms on Pain Sensitivity in the Orofacial Region: A Systematic Review". Journal of Oral & Facial Pain and Headache. 2020, 34(4). 353-363B. https://doi.org/10.11607/ofph.2641

Vancouver

Carvalho Soares FF, Poluha RL, De la Torre Canales G, Costa YM, Nascimento GG, Rodrigues Conti PC et al. Effect of Genetic Polymorphisms on Pain Sensitivity in the Orofacial Region: A Systematic Review. Journal of Oral & Facial Pain and Headache. 2020 Dec;34(4):353-363B. https://doi.org/10.11607/ofph.2641

Author

Carvalho Soares, Flávia Fonseca ; Poluha, Rodrigo Lorenzi ; De la Torre Canales, Giancarlo ; Costa, Yuri Martins ; Nascimento, Gustavo G ; Rodrigues Conti, Paulo César ; Bonjardim, Leonardo Rigoldi. / Effect of Genetic Polymorphisms on Pain Sensitivity in the Orofacial Region : A Systematic Review. In: Journal of Oral & Facial Pain and Headache. 2020 ; Vol. 34, No. 4. pp. 353-363B.

Bibtex

@article{a7a1c2a171ca4667a58a6e901363dd66,
title = "Effect of Genetic Polymorphisms on Pain Sensitivity in the Orofacial Region: A Systematic Review",
abstract = "AIMS: To systematically review the literature to assess whether genetic polymorphisms affect orofacial pain sensitivity in healthy individuals and in patients with chronic orofacial pain disorders.METHODS: Electronic searches were conducted to identify observational studies and clinical trials investigating the association between genetic polymorphisms and orofacial pain sensitivity in healthy individuals and/or patients with chronic orofacial pain disorders. Searches were carried out in PubMed, Embase, and Scopus databases using Medical Subject Headings and free terms.RESULTS: Seven studies fulfilled the eligibility criteria: four analyzed healthy subjects, two included chronic orofacial pain patients, and one included samples of healthy subjects and patients with neuropathic pain. The results showed that genes associated with mechanical and thermal pain sensitivity were mostly related to opioid, catecholaminergic, inflammatory, and dopaminergic pathways.CONCLUSION: Genetic polymorphisms related to opioid, catecholaminergic, inflammatory, and dopaminergic pathways were associated with sensitivity to thermal and pressure stimuli in the orofacial region. Therefore, genetic factors should be taken into account for an accurate interpretation of orofacial pain sensitivity. These results will allow for a better understanding of the etiopathogenesis of chronic pain affecting the orofacial region, and consequently for finding new therapeutic targets.",
keywords = "Chronic Pain/genetics, Facial Pain/genetics, Humans, Pain Threshold, Polymorphism, Genetic, Sensitivity and Specificity, FIBROMYALGIA SYNDROME, chronic pain, pain sensitivity, LOW-BACK-PAIN, PSYCHOLOGICAL-FACTORS, OPIOID RECEPTOR GENE, SINGLE-NUCLEOTIDE POLYMORPHISM, orofacial region, T102C POLYMORPHISM, CATECHOL-O-METHYLTRANSFERASE, INDIVIDUAL-DIFFERENCES, TEMPOROMANDIBULAR-JOINT, POSSIBLE ASSOCIATION, genetic polymorphism, quantitative sensory testing",
author = "{Carvalho Soares}, {Fl{\'a}via Fonseca} and Poluha, {Rodrigo Lorenzi} and {De la Torre Canales}, Giancarlo and Costa, {Yuri Martins} and Nascimento, {Gustavo G} and {Rodrigues Conti}, {Paulo C{\'e}sar} and Bonjardim, {Leonardo Rigoldi}",
year = "2020",
month = dec,
doi = "10.11607/ofph.2641",
language = "English",
volume = "34",
pages = "353--363B",
journal = "Journal of orofacial pain",
issn = "1064-6655",
publisher = "Quintessence Publishing Co., Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Effect of Genetic Polymorphisms on Pain Sensitivity in the Orofacial Region

T2 - A Systematic Review

AU - Carvalho Soares, Flávia Fonseca

AU - Poluha, Rodrigo Lorenzi

AU - De la Torre Canales, Giancarlo

AU - Costa, Yuri Martins

AU - Nascimento, Gustavo G

AU - Rodrigues Conti, Paulo César

AU - Bonjardim, Leonardo Rigoldi

PY - 2020/12

Y1 - 2020/12

N2 - AIMS: To systematically review the literature to assess whether genetic polymorphisms affect orofacial pain sensitivity in healthy individuals and in patients with chronic orofacial pain disorders.METHODS: Electronic searches were conducted to identify observational studies and clinical trials investigating the association between genetic polymorphisms and orofacial pain sensitivity in healthy individuals and/or patients with chronic orofacial pain disorders. Searches were carried out in PubMed, Embase, and Scopus databases using Medical Subject Headings and free terms.RESULTS: Seven studies fulfilled the eligibility criteria: four analyzed healthy subjects, two included chronic orofacial pain patients, and one included samples of healthy subjects and patients with neuropathic pain. The results showed that genes associated with mechanical and thermal pain sensitivity were mostly related to opioid, catecholaminergic, inflammatory, and dopaminergic pathways.CONCLUSION: Genetic polymorphisms related to opioid, catecholaminergic, inflammatory, and dopaminergic pathways were associated with sensitivity to thermal and pressure stimuli in the orofacial region. Therefore, genetic factors should be taken into account for an accurate interpretation of orofacial pain sensitivity. These results will allow for a better understanding of the etiopathogenesis of chronic pain affecting the orofacial region, and consequently for finding new therapeutic targets.

AB - AIMS: To systematically review the literature to assess whether genetic polymorphisms affect orofacial pain sensitivity in healthy individuals and in patients with chronic orofacial pain disorders.METHODS: Electronic searches were conducted to identify observational studies and clinical trials investigating the association between genetic polymorphisms and orofacial pain sensitivity in healthy individuals and/or patients with chronic orofacial pain disorders. Searches were carried out in PubMed, Embase, and Scopus databases using Medical Subject Headings and free terms.RESULTS: Seven studies fulfilled the eligibility criteria: four analyzed healthy subjects, two included chronic orofacial pain patients, and one included samples of healthy subjects and patients with neuropathic pain. The results showed that genes associated with mechanical and thermal pain sensitivity were mostly related to opioid, catecholaminergic, inflammatory, and dopaminergic pathways.CONCLUSION: Genetic polymorphisms related to opioid, catecholaminergic, inflammatory, and dopaminergic pathways were associated with sensitivity to thermal and pressure stimuli in the orofacial region. Therefore, genetic factors should be taken into account for an accurate interpretation of orofacial pain sensitivity. These results will allow for a better understanding of the etiopathogenesis of chronic pain affecting the orofacial region, and consequently for finding new therapeutic targets.

KW - Chronic Pain/genetics

KW - Facial Pain/genetics

KW - Humans

KW - Pain Threshold

KW - Polymorphism, Genetic

KW - Sensitivity and Specificity

KW - FIBROMYALGIA SYNDROME

KW - chronic pain

KW - pain sensitivity

KW - LOW-BACK-PAIN

KW - PSYCHOLOGICAL-FACTORS

KW - OPIOID RECEPTOR GENE

KW - SINGLE-NUCLEOTIDE POLYMORPHISM

KW - orofacial region

KW - T102C POLYMORPHISM

KW - CATECHOL-O-METHYLTRANSFERASE

KW - INDIVIDUAL-DIFFERENCES

KW - TEMPOROMANDIBULAR-JOINT

KW - POSSIBLE ASSOCIATION

KW - genetic polymorphism

KW - quantitative sensory testing

U2 - 10.11607/ofph.2641

DO - 10.11607/ofph.2641

M3 - Review

C2 - 33290441

VL - 34

SP - 353-363B

JO - Journal of orofacial pain

JF - Journal of orofacial pain

SN - 1064-6655

IS - 4

ER -