Effect of Genetic Polymorphisms on Pain Sensitivity in the Orofacial Region: A Systematic Review

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

DOI

  • Flávia Fonseca Carvalho Soares, University of São Paolo, Bauru, Brazil, Brazil
  • Rodrigo Lorenzi Poluha, University of São Paolo, Bauru, Brazil, Brazil
  • Giancarlo De la Torre Canales, University of São Paolo, Bauru, Brazil, Brazil
  • Yuri Martins Costa
  • Gustavo G Nascimento
  • Paulo César Rodrigues Conti, University of São Paolo, Bauru, Brazil, Brazil
  • Leonardo Rigoldi Bonjardim, University of São Paolo, Bauru, Brazil, Brazil

AIMS: To systematically review the literature to assess whether genetic polymorphisms affect orofacial pain sensitivity in healthy individuals and in patients with chronic orofacial pain disorders.

METHODS: Electronic searches were conducted to identify observational studies and clinical trials investigating the association between genetic polymorphisms and orofacial pain sensitivity in healthy individuals and/or patients with chronic orofacial pain disorders. Searches were carried out in PubMed, Embase, and Scopus databases using Medical Subject Headings and free terms.

RESULTS: Seven studies fulfilled the eligibility criteria: four analyzed healthy subjects, two included chronic orofacial pain patients, and one included samples of healthy subjects and patients with neuropathic pain. The results showed that genes associated with mechanical and thermal pain sensitivity were mostly related to opioid, catecholaminergic, inflammatory, and dopaminergic pathways.

CONCLUSION: Genetic polymorphisms related to opioid, catecholaminergic, inflammatory, and dopaminergic pathways were associated with sensitivity to thermal and pressure stimuli in the orofacial region. Therefore, genetic factors should be taken into account for an accurate interpretation of orofacial pain sensitivity. These results will allow for a better understanding of the etiopathogenesis of chronic pain affecting the orofacial region, and consequently for finding new therapeutic targets.

Original languageEnglish
JournalJournal of Oral & Facial Pain and Headache
Volume34
Issue4
Pages (from-to)353-363B
Number of pages13
ISSN1064-6655
DOIs
Publication statusPublished - Dec 2020

    Research areas

  • Chronic Pain/genetics, Facial Pain/genetics, Humans, Pain Threshold, Polymorphism, Genetic, Sensitivity and Specificity, FIBROMYALGIA SYNDROME, chronic pain, pain sensitivity, LOW-BACK-PAIN, PSYCHOLOGICAL-FACTORS, OPIOID RECEPTOR GENE, SINGLE-NUCLEOTIDE POLYMORPHISM, orofacial region, T102C POLYMORPHISM, CATECHOL-O-METHYLTRANSFERASE, INDIVIDUAL-DIFFERENCES, TEMPOROMANDIBULAR-JOINT, POSSIBLE ASSOCIATION, genetic polymorphism, quantitative sensory testing

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