Early detection of ovarian cancer using cell-free DNA fragmentomes and protein biomarkers

Jamie E Medina; Akshaya V Annapragada; Pien Lof; Sarah Short; Adrianna L Bartolomucci; Dimitrios Mathios; Shashikant Koul; Noushin Niknafs; Michael Noe; Zachariah H Foda; Daniel C Bruhm; Carolyn Hruban; Nicholas A Vulpescu; Euihye Jung; Renu Dua; Jenna V Canzoniero; Stephen Cristiano; Vilmos Adleff; Heather Symecko; Daan van den Broek; Lori J Sokoll; Stephen B Baylin; Michael F Press; Dennis J Slamon; Gottfried E Konecny; Christina Therkildsen; Beatriz Carvalho; Gerrit A Meijer; Claus Lindbjerg Andersen; Susan M Domchek; Ronny Drapkin; Robert B Scharpf; Jillian Phallen; Christine A R Lok; Victor E Velculescu

doi:10.1158/2159-8290.CD-24-0393

Early detection of ovarian cancer using cell-free DNA fragmentomes and protein biomarkers

Jamie E Medina, Akshaya V Annapragada, Pien Lof, Sarah Short, Adrianna L Bartolomucci, Dimitrios Mathios, Shashikant Koul, Noushin Niknafs, Michael Noe, Zachariah H Foda, Daniel C Bruhm, Carolyn Hruban, Nicholas A Vulpescu, Euihye Jung, Renu Dua, Jenna V Canzoniero, Stephen Cristiano, Vilmos Adleff, Heather Symecko, Daan van den BroekLori J Sokoll, Stephen B Baylin, Michael F Press, Dennis J Slamon, Gottfried E Konecny, Christina Therkildsen, Beatriz Carvalho, Gerrit A Meijer, Claus Lindbjerg Andersen, Susan M Domchek, Ronny Drapkin, Robert B Scharpf, Jillian Phallen, Christine A R Lok, Victor E Velculescu

Department of Clinical Medicine - Department of Molecular Medicine (MOMA)

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

1 Citation (Scopus)

Abstract

SIGNIFICANCE: There is an unmet need for effective ovarian cancer screening and diagnostic approaches that enable earlier-stage cancer detection and increased overall survival. We have developed a high-performing accessible approach that evaluates cfDNA fragmentomes and protein biomarkers to detect ovarian cancer.

Original language	English
Journal	Cancer Discovery
Volume	15
Issue	1
Pages (from-to)	105-118
Number of pages	14
ISSN	2159-8274
DOIs	https://doi.org/10.1158/2159-8290.CD-24-0393
Publication status	Published - 13 Jan 2025

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Medina, J. E., Annapragada, A. V., Lof, P., Short, S., Bartolomucci, A. L., Mathios, D., Koul, S., Niknafs, N., Noe, M., Foda, Z. H., Bruhm, D. C., Hruban, C., Vulpescu, N. A., Jung, E., Dua, R., Canzoniero, J. V., Cristiano, S., Adleff, V., Symecko, H., ... Velculescu, V. E. (2025). Early detection of ovarian cancer using cell-free DNA fragmentomes and protein biomarkers. Cancer Discovery, 15(1), 105-118. https://doi.org/10.1158/2159-8290.CD-24-0393

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title = "Early detection of ovarian cancer using cell-free DNA fragmentomes and protein biomarkers",

abstract = "SIGNIFICANCE: There is an unmet need for effective ovarian cancer screening and diagnostic approaches that enable earlier-stage cancer detection and increased overall survival. We have developed a high-performing accessible approach that evaluates cfDNA fragmentomes and protein biomarkers to detect ovarian cancer.",

author = "Medina, {Jamie E} and Annapragada, {Akshaya V} and Pien Lof and Sarah Short and Bartolomucci, {Adrianna L} and Dimitrios Mathios and Shashikant Koul and Noushin Niknafs and Michael Noe and Foda, {Zachariah H} and Bruhm, {Daniel C} and Carolyn Hruban and Vulpescu, {Nicholas A} and Euihye Jung and Renu Dua and Canzoniero, {Jenna V} and Stephen Cristiano and Vilmos Adleff and Heather Symecko and {van den Broek}, Daan and Sokoll, {Lori J} and Baylin, {Stephen B} and Press, {Michael F} and Slamon, {Dennis J} and Konecny, {Gottfried E} and Christina Therkildsen and Beatriz Carvalho and Meijer, {Gerrit A} and Andersen, {Claus Lindbjerg} and Domchek, {Susan M} and Ronny Drapkin and Scharpf, {Robert B} and Jillian Phallen and Lok, {Christine A R} and Velculescu, {Victor E}",

year = "2025",

month = jan,

day = "13",

doi = "10.1158/2159-8290.CD-24-0393",

language = "English",

volume = "15",

pages = "105--118",

journal = "Cancer Discovery",

issn = "2159-8274",

publisher = "American Association for Cancer Research Inc.",

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Medina, JE, Annapragada, AV, Lof, P, Short, S, Bartolomucci, AL, Mathios, D, Koul, S, Niknafs, N, Noe, M, Foda, ZH, Bruhm, DC, Hruban, C, Vulpescu, NA, Jung, E, Dua, R, Canzoniero, JV, Cristiano, S, Adleff, V, Symecko, H, van den Broek, D, Sokoll, LJ, Baylin, SB, Press, MF, Slamon, DJ, Konecny, GE, Therkildsen, C, Carvalho, B, Meijer, GA, Andersen, CL, Domchek, SM, Drapkin, R, Scharpf, RB, Phallen, J, Lok, CAR & Velculescu, VE 2025, 'Early detection of ovarian cancer using cell-free DNA fragmentomes and protein biomarkers', Cancer Discovery, vol. 15, no. 1, pp. 105-118. https://doi.org/10.1158/2159-8290.CD-24-0393

TY - JOUR

T1 - Early detection of ovarian cancer using cell-free DNA fragmentomes and protein biomarkers

AU - Medina, Jamie E

AU - Annapragada, Akshaya V

AU - Lof, Pien

AU - Short, Sarah

AU - Bartolomucci, Adrianna L

AU - Mathios, Dimitrios

AU - Koul, Shashikant

AU - Niknafs, Noushin

AU - Noe, Michael

AU - Foda, Zachariah H

AU - Bruhm, Daniel C

AU - Hruban, Carolyn

AU - Vulpescu, Nicholas A

AU - Jung, Euihye

AU - Dua, Renu

AU - Canzoniero, Jenna V

AU - Cristiano, Stephen

AU - Adleff, Vilmos

AU - Symecko, Heather

AU - van den Broek, Daan

AU - Sokoll, Lori J

AU - Baylin, Stephen B

AU - Press, Michael F

AU - Slamon, Dennis J

AU - Konecny, Gottfried E

AU - Therkildsen, Christina

AU - Carvalho, Beatriz

AU - Meijer, Gerrit A

AU - Andersen, Claus Lindbjerg

AU - Domchek, Susan M

AU - Drapkin, Ronny

AU - Scharpf, Robert B

AU - Phallen, Jillian

AU - Lok, Christine A R

AU - Velculescu, Victor E

PY - 2025/1/13

Y1 - 2025/1/13

N2 - SIGNIFICANCE: There is an unmet need for effective ovarian cancer screening and diagnostic approaches that enable earlier-stage cancer detection and increased overall survival. We have developed a high-performing accessible approach that evaluates cfDNA fragmentomes and protein biomarkers to detect ovarian cancer.

AB - SIGNIFICANCE: There is an unmet need for effective ovarian cancer screening and diagnostic approaches that enable earlier-stage cancer detection and increased overall survival. We have developed a high-performing accessible approach that evaluates cfDNA fragmentomes and protein biomarkers to detect ovarian cancer.

UR - http://www.scopus.com/inward/record.url?scp=85213535862&partnerID=8YFLogxK

U2 - 10.1158/2159-8290.CD-24-0393

DO - 10.1158/2159-8290.CD-24-0393

M3 - Journal article

C2 - 39345137

SN - 2159-8274

VL - 15

SP - 105

EP - 118

JO - Cancer Discovery

JF - Cancer Discovery

IS - 1

ER -

Early detection of ovarian cancer using cell-free DNA fragmentomes and protein biomarkers

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