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EAACI Molecular Allergology User's Guide

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DOI

  • P. M. Matricardi, Charite, Charite Medical University of Berlin, Humboldt University of Berlin, Free University of Berlin, Paediat Pneumol & Immunol
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  • J. Kleine-Tebbe, Outpatient Clin Ackermann Hanf & Kleine Tebbe, Allergy & Asthma Ctr Westend
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  • H. J. Hoffmann
  • R. Valenta, Med Univ Vienna, Medical University of Vienna, Div Immunopathol, Dept Pathophysiol & Allergy Res, Ctr Pathophysiol Infectiol & Immunol
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  • C. Hilger, Luxembourg Inst Hlth, Dept Infect & Immunity
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  • S. Hofmaier, Charite, Charite Medical University of Berlin, Humboldt University of Berlin, Free University of Berlin, Paediat Pneumol & Immunol
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  • R. C. Aalberse, Sanquin Res, Dept Immunopathol, Univ Amsterdam, University of Amsterdam, Acad Med Ctr, Landsteiner Lab
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  • I. Agache, Transylvania Univ Brasov, Transylvania University of Brasov, Fac Med, Dept Allergy & Clin Immunol
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  • R. Asero, Clin San Carlo, Ambulatorio Allergol
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  • B. Ballmer-Weber, Univ Zurich Hosp, University of Zurich, Dept Dermatol, Allergy Unit
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  • D. Barber, Univ CEU San Pablo, San Pablo CEU University, IMMA Sch Med
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  • K. Beyer, Charite, Charite Medical University of Berlin, Humboldt University of Berlin, Free University of Berlin, Paediat Pneumol & Immunol
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  • T. Biedermann, Tech Univ Munich, Technical University of Munich, University of Munich, Dept Dermatol & Allergol
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  • M. B. Bilo, Univ Hosp Osped Riuniti Ancona, Dept Internal Med, Allergy Unit
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  • S. Blank, Tech Univ Munich, Helmholtz Association, University of Munich, Technical University of Munich, Helmholtz Ctr Munich, Ctr Allergy & Environm ZAUM
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  • B. Bohle, Med Univ Vienna, Medical University of Vienna, Dept Pathophysiol & Allergy Res, Ctr Pathophysiol Infect & Immunol, Div Expt Allergol
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  • P. P. Bosshard, Univ Zurich Hosp, University of Zurich, Dept Dermatol, Allergy Unit
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  • H. Breiteneder, Med Univ Vienna, Medical University of Vienna, Dept Pathophysiol & Allergy Res
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  • H. A. Brough, Kings Coll London, Guy's & St Thomas' NHS Foundation Trust, University of London, Kings College London, Guys Hosp, Dept Asthma Allergy & Resp Sci, Paediat Allergy
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  • L. Caraballo, Univ Cartagena, Universidad de Cartagena, Immunol Res Inst
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  • J. C. Caubet, Univ Hosp Geneva, University of Geneva, Dept Child & Adolescent, Pediat Allergy Unit
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  • R. Crameri, Univ Zurich, Swiss Institute of Allergy & Asthma Research, University of Zurich, Swiss Inst Allergy & Asthma Res
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  • J. M. Davies, Queensland Univ Technol, Queensland University of Technology (QUT), Sch Biomed Sci, Inst Biomed Innovat
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  • N. Douladiris, Natl & Kapodistrian Univ, University of Athens, Allergy Unit, Paediat Clin 2
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  • M. Ebisawa, Sagamihara Natl Hosp, Dept Allergy, Clin Res Ctr Allergol & Rheumatol
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  • P. A. EIgenmann, Univ Hosp Geneva, University of Geneva, Dept Child & Adolescent, Pediat Allergy Unit
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  • M. Fernandez-Rivas, Hosp Clin San Carlos IdISSC, Dept Allergy
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  • F. Ferreira, Salzburg Univ, Salzburg University, Dept Mol Biol, Div Allergy & Immunol
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  • G. Gadermaier, Salzburg Univ, Salzburg University, Dept Mol Biol, Div Allergy & Immunol
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  • M. Glatz, Univ Zurich Hosp, University of Zurich, Dept Dermatol, Allergy Unit, Christine Kuhne Ctr Allergy Res & Educ CK CARE
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  • R. G. Hamilton, Johns Hopkins Univ, Johns Hopkins University, Sch Med, Dept Med
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  • T. Hawranek, Paracelsus Private Med Univ, Paracelsus Private Medical University, Dept Dermatol
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  • P. Hellings, Acad Med Ctr, Dept Otorhinolaryngol, Univ Hosp Leuven, KU Leuven, University Hospital Leuven, Dept Otorhinolaryngol
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  • K. Hoffmann-Sommergruber, Med Univ Vienna, Medical University of Vienna, Dept Pathophysiol & Allergy Res
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  • T. Jakob, Justus Liebig Univ Giessen, Justus Liebig University Giessen, Dept Dermatol & Allergol, Univ Med Ctr Giessen & Marburg
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  • U. Jappe, German Ctr Lung Res DZL, Div Clin & Mol Allergol, Res Ctr Borstel, Airway Res Ctr North, Univ Lubeck, University of Lubeck, Dept Pneumol, Interdisciplinary Allergy Div
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  • M. Jutel, Wroclaw Med Univ, Dept Clin Immunol, ALL MED Med Res Inst
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  • S. D. Kamath, James Cook Univ, James Cook University, Mol Allergy Res Lab, Ctr Biodiscovery & Mol Dev Therapeut, Australian Inst Trop Hlth & Med
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  • E. F. Knol, Univ Med Ctr Utrecht, University of Utrecht, Utrecht University Medical Center, Dept Immunol, Univ Med Ctr Utrecht, University of Utrecht, Utrecht University Medical Center, Dept Dermatol, Univ Med Ctr Utrecht, University of Utrecht, Utrecht University Medical Center, Dept Allergol
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  • P. Korosec, Univ Clin Resp & Allerg Dis
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  • A. Kuehn, Luxembourg Inst Hlth, Dept Infect & Immunity
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  • G. Lack, Kings Coll London, Kings College London, University of London, MRC & Asthma UK Ctr Allerg Mech Asthma, Guys & St Thomas NHS Fdn Trust, Guy's & St Thomas' NHS Foundation Trust, Div Asthma Allergy & Lung Biol
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  • A. L. Lopata, Wroclaw Med Univ, Dept Clin Immunol, ALL MED Med Res Inst
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  • M. Makela, Univ Helsinki, Helsinki University Central Hospital, University of Helsinki, Skin & Allergy Hosp, Cent Hosp, Univ Helsinki, University of Helsinki
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  • M. Morisset, Ctr Hosp Luxembourg, Natl Serv Immunoallergol
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  • V. Niederberger, Med Univ Vienna, Medical University of Vienna, Dept Otorhinolaryngol
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  • A. H. Nowak-Wezgrzyn, Icahn Sch Med Mt Sinai, Jaffe Food Allergy Inst, Pediat Allergy & Immunol
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  • N. G. Papadopoulos, Univ Manchester, University of Manchester, Inst Human Dev, Ctr Paediat & Child Hlth
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  • E. A. Pastorello, Osped Niguarda Ca Granda, IRCCS Ca Granda Ospedale Maggiore Policlinico, Unit Allergol & Immunol
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  • G. Pauli, Hop Univ Strasbourg, CHU Strasbourg, Serv Pneumol
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  • T. Platts-Mills, Univ Virginia, University of Virginia, Sch Med, Dept Microbiol & Immunol
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  • D. Posa, Charite, Charite Medical University of Berlin, Humboldt University of Berlin, Free University of Berlin, Paediat Pneumol & Immunol
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  • L. K. Poulsen, University of Copenhagen
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  • M. Raulf, Ruhr Univ Bochum IPA, Ruhr University Bochum, German Social Accid Insurance, Inst Prevent & Occupat Med
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  • J. Sastre, Fdn Jimenez Diaz, Div Allergy
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  • E. Scala, IDI IRCCS, IRCCS Istituto Dermopatico dell'Immacolata (IDI), Expt Allergy Unit
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  • J. M. Schmid
  • P. Schmid-Grendelmeier, Univ Zurich Hosp, University of Zurich, Dept Dermatol, Allergy Unit, Christine Kuhne Ctr Allergy Res & Educ CK CARE
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  • M. van Hage, Karolinska Inst, Karolinska Institutet, Clin Immunol & Allergy Unit, Dept Med Solna, Karolinska Univ Hosp, Karolinska Institutet, Karolinska University Hospital
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  • R. van Ree, Univ Amsterdam, University of Amsterdam, Acad Med Ctr, Dept Expt Immunol, Univ Amsterdam, University of Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol
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  • S. Vieths, Paul Ehrlich Inst, Dept Allergol
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  • M. Wickman, Karolinska Inst, Karolinska Institutet, Sachs Childrens Hosp
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  • A. Muraro, Univ Padua, University of Padua, Referral Ctr Food Allergy Diag & Treatment Veneto, Dept Mother & Child Hlth
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  • M. Ollert, Luxembourg Inst Hlth, Dept Infect & Immunity, Univ Southern Denmark, University of Southern Denmark, Dept Dermatol & Allergy Ctr, Odense Res Ctr Anaphylaxis

The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.

Original languageEnglish
JournalPediatric Allergy and Immunology
Volume27
IssueS23
Pages (from-to)1-250
Number of pages250
ISSN0905-6157
DOIs
Publication statusPublished - May 2016

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