Dynamics of circulating dendritic cells and cytokines after kidney transplantation - no effect of remote ischaemic conditioning

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DOI

Inflammation resulting from ischaemia/reperfusion injury can cause kidney graft dysfunction, increase the risk of delayed graft function and possibly reduce long-term graft survival. Remote ischaemic conditioning may protect against ischaemia/reperfusion injury and mitigate the immunological response to the graft. We investigated the immunological effects of remote ischaemic conditioning on kidney transplantation from deceased donors in the randomized CONTEXT study. Three circulating dendritic cell (DC) subtypes identified in peripheral blood from kidney transplant recipients [myeloid DCs, plasmacytoid DCs and immunoglobulin-like transcript (ILT)3 + DCs] were measured at baseline, days 1, 3 and 5 and 1 and 3 months after transplantation. We also quantified 21 cytokines at baseline, days 1 and 5 and 3 months after transplantation. Neither DC counts nor cytokine levels differed between patients receiving remote ischaemic conditioning and controls; however, several parameters exhibited dynamic and parallel alterations in the two groups over time, reflecting the immunological response to the kidney transplantation and immunosuppression.

Original languageEnglish
JournalClinical and Experimental Immunology
Volume206
Issue2
Pages (from-to)226-236
ISSN0964-2536
DOIs
Publication statusPublished - Nov 2021

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    Research areas

  • cytokines, dendritic cells, immunology, kidney transplantation, remote ischaemic conditioning

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