Dynamics of circulating dendritic cells and cytokines after kidney transplantation - no effect of remote ischaemic conditioning

Marie Bodilsen Nielsen; Kristian Ravlo; Marco Eijken; Nicoline V Krogstrup; Morten Bue Svendsen; Chadi Abdel-Halim; Mikkel Steen Petersen; Henrik Birn; Mihai Oltean; Bente Jespersen; Bjarne K Møller

doi:10.1111/cei.13658

Dynamics of circulating dendritic cells and cytokines after kidney transplantation - no effect of remote ischaemic conditioning

Marie Bodilsen Nielsen, Kristian Ravlo, Marco Eijken, Nicoline V Krogstrup, Morten Bue Svendsen, Chadi Abdel-Halim, Mikkel Steen Petersen, Henrik Birn, Mihai Oltean, Bente Jespersen, Bjarne K Møller

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2 Citations (Scopus)

Abstract

Inflammation resulting from ischaemia/reperfusion injury can cause kidney graft dysfunction, increase the risk of delayed graft function and possibly reduce long-term graft survival. Remote ischaemic conditioning may protect against ischaemia/reperfusion injury and mitigate the immunological response to the graft. We investigated the immunological effects of remote ischaemic conditioning on kidney transplantation from deceased donors in the randomized CONTEXT study. Three circulating dendritic cell (DC) subtypes identified in peripheral blood from kidney transplant recipients [myeloid DCs, plasmacytoid DCs and immunoglobulin-like transcript (ILT)3 ⁺ DCs] were measured at baseline, days 1, 3 and 5 and 1 and 3 months after transplantation. We also quantified 21 cytokines at baseline, days 1 and 5 and 3 months after transplantation. Neither DC counts nor cytokine levels differed between patients receiving remote ischaemic conditioning and controls; however, several parameters exhibited dynamic and parallel alterations in the two groups over time, reflecting the immunological response to the kidney transplantation and immunosuppression.

Original language	English
Journal	Clinical and Experimental Immunology
Volume	206
Issue	2
Pages (from-to)	226-236
Number of pages	11
ISSN	0964-2536
DOIs	https://doi.org/10.1111/cei.13658
Publication status	Published - Nov 2021

Keywords

cytokines
dendritic cells
immunology
kidney transplantation
remote ischaemic conditioning

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10.1111/cei.13658

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506117/pdf/CEI-206-226.pdf

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Nielsen, M. B., Ravlo, K., Eijken, M., Krogstrup, N. V., Svendsen, M. B., Abdel-Halim, C., Petersen, M. S., Birn, H., Oltean, M., Jespersen, B., & Møller, B. K. (2021). Dynamics of circulating dendritic cells and cytokines after kidney transplantation - no effect of remote ischaemic conditioning. Clinical and Experimental Immunology, 206(2), 226-236. https://doi.org/10.1111/cei.13658

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title = "Dynamics of circulating dendritic cells and cytokines after kidney transplantation - no effect of remote ischaemic conditioning",

abstract = "Inflammation resulting from ischaemia/reperfusion injury can cause kidney graft dysfunction, increase the risk of delayed graft function and possibly reduce long-term graft survival. Remote ischaemic conditioning may protect against ischaemia/reperfusion injury and mitigate the immunological response to the graft. We investigated the immunological effects of remote ischaemic conditioning on kidney transplantation from deceased donors in the randomized CONTEXT study. Three circulating dendritic cell (DC) subtypes identified in peripheral blood from kidney transplant recipients [myeloid DCs, plasmacytoid DCs and immunoglobulin-like transcript (ILT)3 + DCs] were measured at baseline, days 1, 3 and 5 and 1 and 3 months after transplantation. We also quantified 21 cytokines at baseline, days 1 and 5 and 3 months after transplantation. Neither DC counts nor cytokine levels differed between patients receiving remote ischaemic conditioning and controls; however, several parameters exhibited dynamic and parallel alterations in the two groups over time, reflecting the immunological response to the kidney transplantation and immunosuppression. ",

keywords = "cytokines, dendritic cells, immunology, kidney transplantation, remote ischaemic conditioning",

author = "Nielsen, \{Marie Bodilsen\} and Kristian Ravlo and Marco Eijken and Krogstrup, \{Nicoline V\} and Svendsen, \{Morten Bue\} and Chadi Abdel-Halim and Petersen, \{Mikkel Steen\} and Henrik Birn and Mihai Oltean and Bente Jespersen and M{\o}ller, \{Bjarne K\}",

note = "Publisher Copyright: {\textcopyright} 2021 British Society for Immunology. {\textcopyright} 2021 British Society for Immunology.",

year = "2021",

month = nov,

doi = "10.1111/cei.13658",

language = "English",

volume = "206",

pages = "226--236",

journal = "Clinical and Experimental Immunology",

issn = "0964-2536",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "2",

}

Nielsen, MB, Ravlo, K, Eijken, M, Krogstrup, NV, Svendsen, MB, Abdel-Halim, C, Petersen, MS , Birn, H, Oltean, M, Jespersen, B & Møller, BK 2021, 'Dynamics of circulating dendritic cells and cytokines after kidney transplantation - no effect of remote ischaemic conditioning', Clinical and Experimental Immunology, vol. 206, no. 2, pp. 226-236. https://doi.org/10.1111/cei.13658

Dynamics of circulating dendritic cells and cytokines after kidney transplantation - no effect of remote ischaemic conditioning. / Nielsen, Marie Bodilsen; Ravlo, Kristian; Eijken, Marco et al.
In: Clinical and Experimental Immunology, Vol. 206, No. 2, 11.2021, p. 226-236.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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AU - Nielsen, Marie Bodilsen

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AU - Krogstrup, Nicoline V

AU - Svendsen, Morten Bue

AU - Abdel-Halim, Chadi

AU - Petersen, Mikkel Steen

AU - Birn, Henrik

AU - Oltean, Mihai

AU - Jespersen, Bente

AU - Møller, Bjarne K

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AB - Inflammation resulting from ischaemia/reperfusion injury can cause kidney graft dysfunction, increase the risk of delayed graft function and possibly reduce long-term graft survival. Remote ischaemic conditioning may protect against ischaemia/reperfusion injury and mitigate the immunological response to the graft. We investigated the immunological effects of remote ischaemic conditioning on kidney transplantation from deceased donors in the randomized CONTEXT study. Three circulating dendritic cell (DC) subtypes identified in peripheral blood from kidney transplant recipients [myeloid DCs, plasmacytoid DCs and immunoglobulin-like transcript (ILT)3 + DCs] were measured at baseline, days 1, 3 and 5 and 1 and 3 months after transplantation. We also quantified 21 cytokines at baseline, days 1 and 5 and 3 months after transplantation. Neither DC counts nor cytokine levels differed between patients receiving remote ischaemic conditioning and controls; however, several parameters exhibited dynamic and parallel alterations in the two groups over time, reflecting the immunological response to the kidney transplantation and immunosuppression.

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KW - dendritic cells

KW - immunology

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KW - remote ischaemic conditioning

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DO - 10.1111/cei.13658

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SN - 0964-2536

VL - 206

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EP - 236

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 2

ER -

Dynamics of circulating dendritic cells and cytokines after kidney transplantation - no effect of remote ischaemic conditioning

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