Dynamic nuclear polarization and optimal control spatial-selective 13C MRI and MRS

Mads Sloth Vinding; Christoffer Laustsen; Ivan Maximov; Lise Vejby Søgaard; Jan Henrik Ardenkjær-Larsen; Niels Christian Nielsen

doi:10.1016/j.jmr.2012.12.002

Dynamic nuclear polarization and optimal control spatial-selective 13C MRI and MRS

Mads Sloth Vinding
, Christoffer Laustsen
, Ivan Maximov
, Lise Vejby Søgaard
, Jan Henrik Ardenkjær-Larsen
, Niels Christian Nielsen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

23 Citations (Scopus)

Abstract

Aimed at (13)C metabolic magnetic resonance imaging (MRI) and spectroscopy (MRS) applications, we demonstrate that dynamic nuclear polarization (DNP) may be combined with optimal control 2D spatial selection to simultaneously obtain high sensitivity and well-defined spatial restriction. This is achieved through the development of spatial-selective single-shot spiral-readout MRI and MRS experiments combined with dynamic nuclear polarization hyperpolarized [1-(13)C]pyruvate on a 4.7T pre-clinical MR scanner. The method stands out from related techniques by facilitating anatomic shaped region-of-interest (ROI) single metabolite signals available for higher image resolution or single-peak spectra. The 2D spatial-selective rf pulses were designed using a novel Krotov-based optimal control approach capable of iteratively fast providing successful pulse sequences in the absence of qualified initial guesses. The technique may be important for early detection of abnormal metabolism, monitoring disease progression, and drug research.

Original language	English
Journal	Journal of Magnetic Resonance
Volume	227
Pages (from-to)	57-61
Number of pages	5
ISSN	1090-7807
DOIs	https://doi.org/10.1016/j.jmr.2012.12.002
Publication status	Published - 2013

Access to Document

10.1016/j.jmr.2012.12.002

Library access?

Check availability with the Royal Danish Library

Cite this

@article{3d694e350e3a443ca2aee0b09cf9f92b,

title = "Dynamic nuclear polarization and optimal control spatial-selective 13C MRI and MRS",

abstract = "Aimed at (13)C metabolic magnetic resonance imaging (MRI) and spectroscopy (MRS) applications, we demonstrate that dynamic nuclear polarization (DNP) may be combined with optimal control 2D spatial selection to simultaneously obtain high sensitivity and well-defined spatial restriction. This is achieved through the development of spatial-selective single-shot spiral-readout MRI and MRS experiments combined with dynamic nuclear polarization hyperpolarized [1-(13)C]pyruvate on a 4.7T pre-clinical MR scanner. The method stands out from related techniques by facilitating anatomic shaped region-of-interest (ROI) single metabolite signals available for higher image resolution or single-peak spectra. The 2D spatial-selective rf pulses were designed using a novel Krotov-based optimal control approach capable of iteratively fast providing successful pulse sequences in the absence of qualified initial guesses. The technique may be important for early detection of abnormal metabolism, monitoring disease progression, and drug research.",

author = "Vinding, \{Mads Sloth\} and Christoffer Laustsen and Ivan Maximov and S{\o}gaard, \{Lise Vejby\} and Ardenkj{\ae}r-Larsen, \{Jan Henrik\} and Nielsen, \{Niels Christian\}",

year = "2013",

doi = "10.1016/j.jmr.2012.12.002",

language = "English",

volume = "227",

pages = "57--61",

journal = "Journal of Magnetic Resonance",

issn = "1090-7807",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Dynamic nuclear polarization and optimal control spatial-selective 13C MRI and MRS

AU - Vinding, Mads Sloth

AU - Laustsen, Christoffer

AU - Maximov, Ivan

AU - Søgaard, Lise Vejby

AU - Ardenkjær-Larsen, Jan Henrik

AU - Nielsen, Niels Christian

PY - 2013

Y1 - 2013

N2 - Aimed at (13)C metabolic magnetic resonance imaging (MRI) and spectroscopy (MRS) applications, we demonstrate that dynamic nuclear polarization (DNP) may be combined with optimal control 2D spatial selection to simultaneously obtain high sensitivity and well-defined spatial restriction. This is achieved through the development of spatial-selective single-shot spiral-readout MRI and MRS experiments combined with dynamic nuclear polarization hyperpolarized [1-(13)C]pyruvate on a 4.7T pre-clinical MR scanner. The method stands out from related techniques by facilitating anatomic shaped region-of-interest (ROI) single metabolite signals available for higher image resolution or single-peak spectra. The 2D spatial-selective rf pulses were designed using a novel Krotov-based optimal control approach capable of iteratively fast providing successful pulse sequences in the absence of qualified initial guesses. The technique may be important for early detection of abnormal metabolism, monitoring disease progression, and drug research.

AB - Aimed at (13)C metabolic magnetic resonance imaging (MRI) and spectroscopy (MRS) applications, we demonstrate that dynamic nuclear polarization (DNP) may be combined with optimal control 2D spatial selection to simultaneously obtain high sensitivity and well-defined spatial restriction. This is achieved through the development of spatial-selective single-shot spiral-readout MRI and MRS experiments combined with dynamic nuclear polarization hyperpolarized [1-(13)C]pyruvate on a 4.7T pre-clinical MR scanner. The method stands out from related techniques by facilitating anatomic shaped region-of-interest (ROI) single metabolite signals available for higher image resolution or single-peak spectra. The 2D spatial-selective rf pulses were designed using a novel Krotov-based optimal control approach capable of iteratively fast providing successful pulse sequences in the absence of qualified initial guesses. The technique may be important for early detection of abnormal metabolism, monitoring disease progression, and drug research.

U2 - 10.1016/j.jmr.2012.12.002

DO - 10.1016/j.jmr.2012.12.002

M3 - Journal article

C2 - 23298857

SN - 1090-7807

VL - 227

SP - 57

EP - 61

JO - Journal of Magnetic Resonance

JF - Journal of Magnetic Resonance

ER -

Dynamic nuclear polarization and optimal control spatial-selective 13C MRI and MRS

Abstract

Access to Document

Library access?

Fingerprint

Cite this