Dynamic Contrast Enhanced (DCE) MRI-Derived Renal Perfusion and Filtration: Experimental Protocol

Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  • Pietro Irrera, University of Campania Luigi Vanvitelli
  • ,
  • Lorena Consolino, University Torino, Clinic for Cardiac Surgery, Torino
  • ,
  • Walter Dastrù, University Torino, Clinic for Cardiac Surgery, Torino
  • ,
  • Michael Pedersen
  • Frank G Zöllner, Heidelberg Univ, Ruprecht Karl University Heidelberg, Dept Phys & Astron Heidelberg
  • ,
  • Dario Livio Longo, Institute of Biostructures and Bioimaging (IBB)

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can provide a noninvasive way for assessing renal functional information following the administration of a small molecular weight gadolinium-based contrast agent. This method may be useful for investigating renal perfusion and glomerular filtration rates of rodents in vivo under various experimental (patho)physiological conditions. Here we describe a step-by-step protocol for DCE-MRI studies in small animals providing practical notes on acquisition parameters, sequences, T1 mapping approaches and procedures.This chapters is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This experimental protocol chapter is complemented by two separate chapters describing the basic concept and data analysis.

Original languageEnglish
Title of host publicationPreclinical MRI of the Kidney : Methods and Protocols
EditorsAndreas Pohlmann, Thoralf Niendorf
Number of pages13
PublisherHumana Press
Publication year2021
ISBN (print)978-1-0716-0977-4
ISBN (Electronic)978-1-0716-0978-1
Publication statusPublished - 2021
SeriesMethods in Molecular Biology

    Research areas

  • Contrast agent, Dynamic contrast-enhanced (DCE), Kidney, Magnetic resonance imaging (MRI), Mice, Rats, T map

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