Department of Economics and Business Economics

Dual association of a TRKA polymorphism with schizophrenia

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  • Jessica E Van Schijndel
  • ,
  • Martine Van Zweeden
  • ,
  • Karen M J Van Loo
  • ,
  • Srdjan Djurovic
  • ,
  • Ole A Andreassen
  • ,
  • Thomas Werge
  • ,
  • Mette Nyegaard
  • Karina Meden Sørensen
  • ,
  • Merete Nordentoft
  • ,
  • Preben B Mortensen
  • Ole Mors
  • Anders D Børglum
  • Jurgen Del-Favero
  • ,
  • Karl-Fredrik Norrback
  • ,
  • Rolf Adolfsson
  • ,
  • Marc De Hert
  • ,
  • Stephan Claes
  • ,
  • Sven Cichon
  • ,
  • Marcella Rietschel
  • ,
  • Markus M Nöthen
  • ,
  • Pekka Kallunki
  • ,
  • Jan T Pedersen
  • Hæmatologisk Afdeling, Aalborg Sygehus
  • Department of Human Genetics
  • National Centre for Register-based Research
  • Centre for Psychiatric Research
OBJECTIVE: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor. METHODS: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups. RESULT: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor. CONCLUSION: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors.
Original languageEnglish
JournalPsychiatric Genetics
Volume21
Issue3
Pages (from-to)125-131
ISSN0955-8829
DOIs
Publication statusPublished - 10 Feb 2011

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