Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient

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DOI

  • Paola Piccini, Hammersmith Hospital
  • ,
  • David J. Brooks
  • Anders Björklund, Lunds Universitet
  • ,
  • Roger N. Gunn, Hammersmith Hospital
  • ,
  • Paul M. Grasby, Hammersmith Hospital
  • ,
  • Ornella Rimoldi, Hammersmith Hospital
  • ,
  • Patrik Brundin, Lunds Universitet
  • ,
  • Peter Hagell, Lunds Universitet, Lund University Hospital
  • ,
  • Stig Rehncrona, Lund University Hospital
  • ,
  • Håkan Widner, Lunds Universitet, Lund University Hospital
  • ,
  • Olle Lindvall, Lunds Universitet, Lund University Hospital

Synaptic dopamine release from embryonic nigral transplants has been monitored in the striatum of a patient with Parkinson's disease using [11C]-raclopride positron emission tomography to measure dopamine D2 receptor occupancy by the endogenous transmitter. In this patient, who had received a transplant in the right putamen 10 years earlier, grafts had restored both basal and drug-induced dopamine release to normal levels. This was associated with sustained, marked clinical benefit and normalized levels of dopamine storage in the grafted putamen. Despite an ongoing disease process, grafted neurons can thus continue for a decade to store and release dopamine and give rise to substantial symptomatic relief.

Original languageEnglish
JournalNature Neuroscience
Volume2
Issue12
Pages (from-to)1137-1140
Number of pages4
ISSN1097-6256
DOIs
Publication statusPublished - 1 Dec 1999
Externally publishedYes

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