DNA-templated covalent coupling of G4 PAMAM dendrimers

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  • Interdisciplinary Nanoscience Center
  • Communications Center Science
  • Department of Physics and Astronomy
  • Department of Chemistry
  • iNano-School
Generation-4 polyamidoamine (PAMAM) dendrimers were surface-functionalized with azides or alkynes and conjugated to one DNA strand. DNA-controlled self-assembly of alternating azide and alkyne dendrimers on a DNA template enabled the coupling of the dendrimers by the azide-alkyne "click" reaction to form covalently coupled dimers, trimers, and tetramers. Polymerization of the DNA-dendrimer conjugates was also demonstrated, as well as assembly in a circular structure on DNA origami and imaging by atomic force microscopy.
Original languageEnglish
JournalJournal of the American Chemical Society
Volume132
Issue51
Pages (from-to)18054-6
Number of pages3
ISSN0002-7863
DOIs
Publication statusPublished - 29 Dec 2010

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