DNA nanovehicles and the biological barriers

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DNA nanovehicles and the biological barriers. / Okholm, Anders Hauge; Kjems, Jørgen.

In: Advanced Drug Delivery Reviews, Vol. 106, No. Part A, 16, 15.11.2016, p. 183-191.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Harvard

Okholm, AH & Kjems, J 2016, 'DNA nanovehicles and the biological barriers', Advanced Drug Delivery Reviews, vol. 106, no. Part A, 16, pp. 183-191. https://doi.org/10.1016/j.addr.2016.05.024

APA

Okholm, A. H., & Kjems, J. (2016). DNA nanovehicles and the biological barriers. Advanced Drug Delivery Reviews, 106(Part A), 183-191. [16]. https://doi.org/10.1016/j.addr.2016.05.024

CBE

Okholm AH, Kjems J. 2016. DNA nanovehicles and the biological barriers. Advanced Drug Delivery Reviews. 106(Part A):183-191. https://doi.org/10.1016/j.addr.2016.05.024

MLA

Okholm, Anders Hauge and Jørgen Kjems. "DNA nanovehicles and the biological barriers". Advanced Drug Delivery Reviews. 2016, 106(Part A). 183-191. https://doi.org/10.1016/j.addr.2016.05.024

Vancouver

Okholm AH, Kjems J. DNA nanovehicles and the biological barriers. Advanced Drug Delivery Reviews. 2016 Nov 15;106(Part A):183-191. 16. https://doi.org/10.1016/j.addr.2016.05.024

Author

Okholm, Anders Hauge ; Kjems, Jørgen. / DNA nanovehicles and the biological barriers. In: Advanced Drug Delivery Reviews. 2016 ; Vol. 106, No. Part A. pp. 183-191.

Bibtex

@article{bedb70243c884f579be357cde17ed174,
title = "DNA nanovehicles and the biological barriers",
abstract = "DNA is emerging as a smart material to construct nanovehicles for targeted drug delivery. The programmability of Watson-Crick base paring enables construction of defined and dynamic DNA nanostructures of almost arbitrary shape and DNA can readily be functionalized with a variety of molecular modules. The applications of DNA nanostructures are still in its infancy, but one of the high expectations are to deliver solutions for targeted therapy. Nucleic acids, however, do not easily enter cells unassisted and biological barriers and harsh nucleolytic conditions in the human body must also be overcome. Here, we highlight recent strategies for DNA nanostructures in drug delivery, DNA nanovehicles, to facilitate targeting and crossing of the biological barriers. In light of this, we discuss future solutions and challenges for DNA nanovehicles to unravel their great potential to facilitate targeted drug delivery.",
author = "Okholm, {Anders Hauge} and J{\o}rgen Kjems",
year = "2016",
month = "11",
day = "15",
doi = "10.1016/j.addr.2016.05.024",
language = "English",
volume = "106",
pages = "183--191",
journal = "Advanced Drug Delivery Reviews",
issn = "0169-409X",
publisher = "Elsevier BV",
number = "Part A",

}

RIS

TY - JOUR

T1 - DNA nanovehicles and the biological barriers

AU - Okholm, Anders Hauge

AU - Kjems, Jørgen

PY - 2016/11/15

Y1 - 2016/11/15

N2 - DNA is emerging as a smart material to construct nanovehicles for targeted drug delivery. The programmability of Watson-Crick base paring enables construction of defined and dynamic DNA nanostructures of almost arbitrary shape and DNA can readily be functionalized with a variety of molecular modules. The applications of DNA nanostructures are still in its infancy, but one of the high expectations are to deliver solutions for targeted therapy. Nucleic acids, however, do not easily enter cells unassisted and biological barriers and harsh nucleolytic conditions in the human body must also be overcome. Here, we highlight recent strategies for DNA nanostructures in drug delivery, DNA nanovehicles, to facilitate targeting and crossing of the biological barriers. In light of this, we discuss future solutions and challenges for DNA nanovehicles to unravel their great potential to facilitate targeted drug delivery.

AB - DNA is emerging as a smart material to construct nanovehicles for targeted drug delivery. The programmability of Watson-Crick base paring enables construction of defined and dynamic DNA nanostructures of almost arbitrary shape and DNA can readily be functionalized with a variety of molecular modules. The applications of DNA nanostructures are still in its infancy, but one of the high expectations are to deliver solutions for targeted therapy. Nucleic acids, however, do not easily enter cells unassisted and biological barriers and harsh nucleolytic conditions in the human body must also be overcome. Here, we highlight recent strategies for DNA nanostructures in drug delivery, DNA nanovehicles, to facilitate targeting and crossing of the biological barriers. In light of this, we discuss future solutions and challenges for DNA nanovehicles to unravel their great potential to facilitate targeted drug delivery.

U2 - 10.1016/j.addr.2016.05.024

DO - 10.1016/j.addr.2016.05.024

M3 - Review

VL - 106

SP - 183

EP - 191

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

IS - Part A

M1 - 16

ER -