DNA Electrochemistry and Electrochemical Sensors for Nucleic Acids

TY - JOUR

T1 - DNA Electrochemistry and Electrochemical Sensors for Nucleic Acids

AU - Ferapontova, Elena E.

PY - 2018/6/12

Y1 - 2018/6/12

N2 - Sensitive, specific, and fast analysis of nucleic acids (NAs) is strongly needed in medicine, environmental science, biodefence, and agriculture for the study of bacterial contamination of food and beverages and genetically modified organisms. Electrochemistry offers accurate, simple, inexpensive, and robust tools for the development of such analytical platforms that can successfully compete with other approaches for NA detection. Here, electrode reactions of DNA, basic principles of electrochemical NA analysis, and their relevance for practical applications are reviewed and critically discussed.

AB - Sensitive, specific, and fast analysis of nucleic acids (NAs) is strongly needed in medicine, environmental science, biodefence, and agriculture for the study of bacterial contamination of food and beverages and genetically modified organisms. Electrochemistry offers accurate, simple, inexpensive, and robust tools for the development of such analytical platforms that can successfully compete with other approaches for NA detection. Here, electrode reactions of DNA, basic principles of electrochemical NA analysis, and their relevance for practical applications are reviewed and critically discussed.

KW - DNA-mediated electron transfer

KW - electrocatalytic sensors

KW - electrochemical beacons

KW - electrochemical DNA biosensors

KW - hybridization

KW - redox indicators

U2 - 10.1146/annurev-anchem-061417-125811

DO - 10.1146/annurev-anchem-061417-125811

M3 - Review

C2 - 29894229

AN - SCOPUS:85048640493

SN - 1936-1327

VL - 11

SP - 197

EP - 218

JO - Annual Review of Analytical Chemistry

JF - Annual Review of Analytical Chemistry

ER -