Distributed neural actions of anti-parkinsonian therapies as revealed by PET

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • I. K. Goerendt, Hammersmith Hospital
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  • A. D. Lawrence, Hammersmith Hospital, MRC Cognition and Brain Sciences Unit, Cambridge
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  • M. A. Mehta, Hammersmith Hospital
  • ,
  • J. S. Stern, Hammersmith Hospital
  • ,
  • P. Odin, Philipps-Universität Marburg
  • ,
  • D. J. Brooks

There is a limited understanding of how different anti-parkinsonian treatments act at the neuronal systems level. Using positron emission tomography we examined the effects of levodopa and deep brain stimulation of the subthalamic nucleus on patterns of regional cerebral blood flow in patients with Parkinson's disease during a homogenous cognitive-behavioural state rather than during an unspecified resting state. We found that when medicated precuneus, frontal, parietal, cerebellar and midbrain areas were relatively more activated than when stimulated, whereas when stimulated the precentral gyrus, caudate and thalamus were relatively more activated than when medicated. Areas that were activated by both treatments included the temporal gyri, anterior thalamus, and midbrain. Regions of prefrontal cortex showed relatively greater activation in the "off treatment" conditions of both the medicated and stimulated groups. Our findings suggest that the two treatment methods may lead to symptomatic relief via both common and different sites of action.

Original languageEnglish
JournalJournal of Neural Transmission
Volume113
Issue1
Pages (from-to)75-86
Number of pages12
ISSN0300-9564
DOIs
Publication statusPublished - 1 Jan 2006
Externally publishedYes

    Research areas

  • Deep brain stimulation, Levodopa, Positron emission tomography

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