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Disruption of Na+,HCO₃⁻ cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca²⁺ sensitivity, and hypertension development in mice
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Disturbances in pH affect artery function, but the mechanistic background remains controversial. We investigated whether Na(+), HCO₃- transporter NBCn1, by regulating intracellular pH(pH₁), influences artery function and blood pressure regulation.
| Original language | English |
|---|---|
| Journal | Circulation |
| Volume | 124 |
| Issue | 17 |
| Pages (from-to) | 1819-1829 |
| Number of pages | 11 |
| ISSN | 0009-7322 |
| DOIs | |
| Publication status | Published - 26 Sep 2011 |
- Animals, Calcium, Calcium Signaling, Endothelium, Vascular, Hypertension, Mesenteric Arteries, Mice, Mice, Inbred C57BL, Mice, Knockout, Muscle, Smooth, Vascular, Nitric Oxide, Organ Culture Techniques, Sodium-Bicarbonate Symporters, Sodium-Hydrogen Antiporter, Vasodilation
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ID: 48741064