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Disruption of Na+,HCO₃⁻ cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca²⁺ sensitivity, and hypertension development in mice

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Disturbances in pH affect artery function, but the mechanistic background remains controversial. We investigated whether Na(+), HCO₃- transporter NBCn1, by regulating intracellular pH(pH₁), influences artery function and blood pressure regulation.
Original languageEnglish
Pages (from-to)1819-1829
Number of pages11
Publication statusPublished - 26 Sep 2011

    Research areas

  • Animals, Calcium, Calcium Signaling, Endothelium, Vascular, Hypertension, Mesenteric Arteries, Mice, Mice, Inbred C57BL, Mice, Knockout, Muscle, Smooth, Vascular, Nitric Oxide, Organ Culture Techniques, Sodium-Bicarbonate Symporters, Sodium-Hydrogen Antiporter, Vasodilation

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