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Directing HER4 mRNA expression towards the CYT2 isoform by antisense oligonucleotide decreases growth of breast cancer cells in vitro and in vivo

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  • Trine O Nielsen, Department of Clinical Biochemistry, Aarhus University , Denmark
  • Suzette Sorensen, Denmark
  • Frederik Dagnæs-Hansen, Denmark
  • Jørgen Kjems
  • Boe Sandahl Sørensen
The tyrosine kinase receptor HER4 is a member of the epidermal growth factor receptor (EGFR) family. It plays diverse roles in cancer development and cancer progression and can both exert oncogenic and tumour-suppressive activities. Alternatively spliced isoforms of HER4 are critical to the different signalling possibilities of HER4.
Original languageEnglish
JournalB J C
Pages (from-to)2291-2298
Number of pages8
Publication statusPublished - 11 Jun 2013

    Research areas

  • Alternative Splicing, Animals, Breast Neoplasms, Cell Line, Tumor, Female, Humans, Isoenzymes, MCF-7 Cells, Mice, Mice, Inbred C3H, Mice, Nude, Oligonucleotides, Antisense, RNA, Messenger, Random Allocation, Receptor, Epidermal Growth Factor, Xenograft Model Antitumor Assays

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