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Final published version
An extensive range of functionalized aliphatic ketones with good functional-group tolerance has been prepared by a NiI-promoted coupling of either primary or secondary alkyl iodides with NN2 pincer NiII-acyl complexes. The latter were easily accessed from the corresponding NiII-alkyl complexes with stoichiometric CO. This Ni-mediated carbonylative coupling is adaptable to late-stage carbon isotope labeling, as illustrated by the preparation of isotopically labelled pharmaceuticals. Preliminary investigations suggest the intermediacy of carbon-centered radicals.
Original language | English |
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Journal | Angewandte Chemie - International Edition |
Volume | 59 |
Issue | 21 |
Pages (from-to) | 8099-8103 |
Number of pages | 5 |
ISSN | 1433-7851 |
DOIs | |
Publication status | Published - May 2020 |
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ID: 186542784