Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations

Niels Herluf Paulsen; Camilla Qvortrup; Fie Juhl Vojdeman; Peter Plomgaard; Stig Ejdrup Andersen; Anne Ramlov; Birgitte Bertelsen; Maria Rossing; Claus Gyrup Nielsen; Elke Hoffmann-Lücke; Eva Greibe; Hanne Spangsberg Holm; Heidi Hvid Nielsen; Ihab Bishara Yousef Lolas; Jonna Skov Madsen; Marianne Lerbaek Bergmann; Morten Mørk; Palle B.Nielsen Fruekilde; Pernille Bøttger; Peter Clausager Petersen; Peter Henrik Nissen; Søren Feddersen; Troels K. Bergmann; Per Pfeiffer; Per Damkier

doi:10.1080/0284186X.2022.2132117

Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations

Niels Herluf Paulsen^*, Camilla Qvortrup, Fie Juhl Vojdeman, Peter Plomgaard, Stig Ejdrup Andersen, Anne Ramlov, Birgitte Bertelsen, Maria Rossing, Claus Gyrup Nielsen, Elke Hoffmann-Lücke, Eva Greibe, Hanne Spangsberg Holm, Heidi Hvid Nielsen, Ihab Bishara Yousef Lolas, Jonna Skov Madsen, Marianne Lerbaek Bergmann, Morten Mørk, Palle B.Nielsen Fruekilde, Pernille Bøttger, Peter Clausager PetersenPeter Henrik Nissen, Søren Feddersen, Troels K. Bergmann, Per Pfeiffer, Per Damkier

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research › peer-review

4 Citations (Scopus)

Original language	English
Journal	Acta Oncologica
Volume	61
Issue	11
Pages (from-to)	1400-1405
Number of pages	6
ISSN	0284-186X
DOIs	https://doi.org/10.1080/0284186X.2022.2132117
Publication status	Published - Nov 2022

Keywords

Denmark/epidemiology
Dihydrouracil Dehydrogenase (NADP)/genetics
Fluorouracil
Genotype
Humans
Neoplasms/epidemiology
Phenotype
Prevalence
Uracil

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10.1080/0284186X.2022.2132117

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Paulsen, N. H., Qvortrup, C., Vojdeman, F. J., Plomgaard, P., Andersen, S. E., Ramlov, A., Bertelsen, B., Rossing, M., Nielsen, C. G., Hoffmann-Lücke, E., Greibe, E., Spangsberg Holm, H., Nielsen, H. H., Lolas, I. B. Y., Madsen, J. S., Bergmann, M. L., Mørk, M., Fruekilde, P. B. N., Bøttger, P., ... Damkier, P. (2022). Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations. Acta Oncologica, 61(11), 1400-1405 . https://doi.org/10.1080/0284186X.2022.2132117

@article{26076933fad644e5b4327d76eb5c7095,

title = "Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations",

keywords = "Denmark/epidemiology, Dihydrouracil Dehydrogenase (NADP)/genetics, Fluorouracil, Genotype, Humans, Neoplasms/epidemiology, Phenotype, Prevalence, Uracil",

author = "Paulsen, {Niels Herluf} and Camilla Qvortrup and Vojdeman, {Fie Juhl} and Peter Plomgaard and Andersen, {Stig Ejdrup} and Anne Ramlov and Birgitte Bertelsen and Maria Rossing and Nielsen, {Claus Gyrup} and Elke Hoffmann-L{\"u}cke and Eva Greibe and {Spangsberg Holm}, Hanne and Nielsen, {Heidi Hvid} and Lolas, {Ihab Bishara Yousef} and Madsen, {Jonna Skov} and Bergmann, {Marianne Lerbaek} and Morten M{\o}rk and Fruekilde, {Palle B.Nielsen} and Pernille B{\o}ttger and Petersen, {Peter Clausager} and Nissen, {Peter Henrik} and S{\o}ren Feddersen and Bergmann, {Troels K.} and Per Pfeiffer and Per Damkier",

note = "Funding Information: This work was supported by the The Region of Southern Denmark and the Danish Cancer Society.",

year = "2022",

month = nov,

doi = "10.1080/0284186X.2022.2132117",

language = "English",

volume = "61",

pages = "1400--1405 ",

journal = "Acta Oncologica",

issn = "0284-186X",

publisher = "Medical Journals Sweden AB",

number = "11",

}

Paulsen, NH, Qvortrup, C, Vojdeman, FJ, Plomgaard, P, Andersen, SE, Ramlov, A, Bertelsen, B, Rossing, M, Nielsen, CG, Hoffmann-Lücke, E , Greibe, E, Spangsberg Holm, H, Nielsen, HH, Lolas, IBY, Madsen, JS, Bergmann, ML, Mørk, M, Fruekilde, PBN, Bøttger, P, Petersen, PC, Nissen, PH, Feddersen, S, Bergmann, TK, Pfeiffer, P & Damkier, P 2022, 'Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations', Acta Oncologica, vol. 61, no. 11, pp. 1400-1405 . https://doi.org/10.1080/0284186X.2022.2132117

Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations. / Paulsen, Niels Herluf; Qvortrup, Camilla; Vojdeman, Fie Juhl et al.
In: Acta Oncologica, Vol. 61, No. 11, 11.2022, p. 1400-1405 .

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research › peer-review

TY - JOUR

T1 - Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients

T2 - prevalence and correlation between DPYD-genotype variants and P-uracil concentrations

AU - Paulsen, Niels Herluf

AU - Qvortrup, Camilla

AU - Vojdeman, Fie Juhl

AU - Plomgaard, Peter

AU - Andersen, Stig Ejdrup

AU - Ramlov, Anne

AU - Bertelsen, Birgitte

AU - Rossing, Maria

AU - Nielsen, Claus Gyrup

AU - Hoffmann-Lücke, Elke

AU - Greibe, Eva

AU - Spangsberg Holm, Hanne

AU - Nielsen, Heidi Hvid

AU - Lolas, Ihab Bishara Yousef

AU - Madsen, Jonna Skov

AU - Bergmann, Marianne Lerbaek

AU - Mørk, Morten

AU - Fruekilde, Palle B.Nielsen

AU - Bøttger, Pernille

AU - Petersen, Peter Clausager

AU - Nissen, Peter Henrik

AU - Feddersen, Søren

AU - Bergmann, Troels K.

AU - Pfeiffer, Per

AU - Damkier, Per

N1 - Funding Information: This work was supported by the The Region of Southern Denmark and the Danish Cancer Society.

PY - 2022/11

Y1 - 2022/11

KW - Denmark/epidemiology

KW - Dihydrouracil Dehydrogenase (NADP)/genetics

KW - Fluorouracil

KW - Genotype

KW - Humans

KW - Neoplasms/epidemiology

KW - Phenotype

KW - Prevalence

KW - Uracil

UR - http://www.scopus.com/inward/record.url?scp=85140114839&partnerID=8YFLogxK

U2 - 10.1080/0284186X.2022.2132117

DO - 10.1080/0284186X.2022.2132117

M3 - Comment/debate/letter to the editor

C2 - 36256873

AN - SCOPUS:85140114839

SN - 0284-186X

VL - 61

SP - 1400

EP - 1405

JO - Acta Oncologica

JF - Acta Oncologica

IS - 11

ER -

Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations

Keywords

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