Differentiated effects of deep brain stimulation and medication on somatosensory processing in Parkinson's disease

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Standard

Differentiated effects of deep brain stimulation and medication on somatosensory processing in Parkinson's disease. / Sridharan, Kousik Sarathy; Højlund, Andreas; Johnsen, Erik Lisbjerg; Sunde, Niels; Johansen, Lars Gottfried; Beniczky, Sándor; Østergaard, Karen.

In: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, Vol. 128, No. 7, 07.2017, p. 1327-1336.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Sridharan, KS, Højlund, A, Johnsen, EL, Sunde, N, Johansen, LG, Beniczky, S & Østergaard, K 2017, 'Differentiated effects of deep brain stimulation and medication on somatosensory processing in Parkinson's disease', Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, vol. 128, no. 7, pp. 1327-1336. https://doi.org/10.1016/j.clinph.2017.04.014

APA

Sridharan, K. S., Højlund, A., Johnsen, E. L., Sunde, N., Johansen, L. G., Beniczky, S., & Østergaard, K. (2017). Differentiated effects of deep brain stimulation and medication on somatosensory processing in Parkinson's disease. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 128(7), 1327-1336. https://doi.org/10.1016/j.clinph.2017.04.014

CBE

Sridharan KS, Højlund A, Johnsen EL, Sunde N, Johansen LG, Beniczky S, Østergaard K. 2017. Differentiated effects of deep brain stimulation and medication on somatosensory processing in Parkinson's disease. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 128(7):1327-1336. https://doi.org/10.1016/j.clinph.2017.04.014

MLA

Sridharan, Kousik Sarathy et al. "Differentiated effects of deep brain stimulation and medication on somatosensory processing in Parkinson's disease". Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2017, 128(7). 1327-1336. https://doi.org/10.1016/j.clinph.2017.04.014

Vancouver

Sridharan KS, Højlund A, Johnsen EL, Sunde N, Johansen LG, Beniczky S et al. Differentiated effects of deep brain stimulation and medication on somatosensory processing in Parkinson's disease. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2017 Jul;128(7):1327-1336. https://doi.org/10.1016/j.clinph.2017.04.014

Author

Sridharan, Kousik Sarathy ; Højlund, Andreas ; Johnsen, Erik Lisbjerg ; Sunde, Niels ; Johansen, Lars Gottfried ; Beniczky, Sándor ; Østergaard, Karen. / Differentiated effects of deep brain stimulation and medication on somatosensory processing in Parkinson's disease. In: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2017 ; Vol. 128, No. 7. pp. 1327-1336.

Bibtex

@article{0aec81ea23db4d09afe5e91b9cb5d758,
title = "Differentiated effects of deep brain stimulation and medication on somatosensory processing in Parkinson's disease",
abstract = "OBJECTIVES: Deep brain stimulation (DBS) and dopaminergic medication effectively alleviate the motor symptoms in Parkinson's disease (PD) patients, but their effects on the sensory symptoms of PD are still not well understood. To explore early somatosensory processing in PD, we recorded magnetoencephalography (MEG) from thirteen DBS-treated PD patients and ten healthy controls during median nerve stimulation.METHODS: PD patients were measured during DBS-treated, untreated and dopaminergic-medicated states. We focused on early cortical somatosensory processing as indexed by N20m, induced gamma augmentation (31-45Hz and 55-100Hz) and induced beta suppression (13-30Hz). PD patients' motor symptoms were assessed by UPDRS-III.RESULTS: Using Bayesian statistics, we found positive evidence for differentiated effects of treatments on the induced gamma augmentation (31-45Hz) with highest gamma in the dopaminergic-medicated state and lowest in the DBS-treated and untreated states. In contrast, UPDRS-III scores showed beneficial effects of both DBS and dopaminergic medication on the patients' motor symptoms. Furthermore, treatments did not affect the amplitude of N20m.CONCLUSIONS: Our results suggest differentiated effects of DBS and dopaminergic medication on cortical somatosensory processing in PD patients despite consistent ameliorating effects of both treatments on PD motor symptoms.SIGNIFICANCE: The differentiated effect suggests differences in the effect mechanisms of the two treatments.",
keywords = "Journal Article",
author = "Sridharan, {Kousik Sarathy} and Andreas H{\o}jlund and Johnsen, {Erik Lisbjerg} and Niels Sunde and Johansen, {Lars Gottfried} and S{\'a}ndor Beniczky and Karen {\O}stergaard",
note = "Copyright {\textcopyright} 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.",
year = "2017",
month = jul,
doi = "10.1016/j.clinph.2017.04.014",
language = "English",
volume = "128",
pages = "1327--1336",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd.",
number = "7",

}

RIS

TY - JOUR

T1 - Differentiated effects of deep brain stimulation and medication on somatosensory processing in Parkinson's disease

AU - Sridharan, Kousik Sarathy

AU - Højlund, Andreas

AU - Johnsen, Erik Lisbjerg

AU - Sunde, Niels

AU - Johansen, Lars Gottfried

AU - Beniczky, Sándor

AU - Østergaard, Karen

N1 - Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

PY - 2017/7

Y1 - 2017/7

N2 - OBJECTIVES: Deep brain stimulation (DBS) and dopaminergic medication effectively alleviate the motor symptoms in Parkinson's disease (PD) patients, but their effects on the sensory symptoms of PD are still not well understood. To explore early somatosensory processing in PD, we recorded magnetoencephalography (MEG) from thirteen DBS-treated PD patients and ten healthy controls during median nerve stimulation.METHODS: PD patients were measured during DBS-treated, untreated and dopaminergic-medicated states. We focused on early cortical somatosensory processing as indexed by N20m, induced gamma augmentation (31-45Hz and 55-100Hz) and induced beta suppression (13-30Hz). PD patients' motor symptoms were assessed by UPDRS-III.RESULTS: Using Bayesian statistics, we found positive evidence for differentiated effects of treatments on the induced gamma augmentation (31-45Hz) with highest gamma in the dopaminergic-medicated state and lowest in the DBS-treated and untreated states. In contrast, UPDRS-III scores showed beneficial effects of both DBS and dopaminergic medication on the patients' motor symptoms. Furthermore, treatments did not affect the amplitude of N20m.CONCLUSIONS: Our results suggest differentiated effects of DBS and dopaminergic medication on cortical somatosensory processing in PD patients despite consistent ameliorating effects of both treatments on PD motor symptoms.SIGNIFICANCE: The differentiated effect suggests differences in the effect mechanisms of the two treatments.

AB - OBJECTIVES: Deep brain stimulation (DBS) and dopaminergic medication effectively alleviate the motor symptoms in Parkinson's disease (PD) patients, but their effects on the sensory symptoms of PD are still not well understood. To explore early somatosensory processing in PD, we recorded magnetoencephalography (MEG) from thirteen DBS-treated PD patients and ten healthy controls during median nerve stimulation.METHODS: PD patients were measured during DBS-treated, untreated and dopaminergic-medicated states. We focused on early cortical somatosensory processing as indexed by N20m, induced gamma augmentation (31-45Hz and 55-100Hz) and induced beta suppression (13-30Hz). PD patients' motor symptoms were assessed by UPDRS-III.RESULTS: Using Bayesian statistics, we found positive evidence for differentiated effects of treatments on the induced gamma augmentation (31-45Hz) with highest gamma in the dopaminergic-medicated state and lowest in the DBS-treated and untreated states. In contrast, UPDRS-III scores showed beneficial effects of both DBS and dopaminergic medication on the patients' motor symptoms. Furthermore, treatments did not affect the amplitude of N20m.CONCLUSIONS: Our results suggest differentiated effects of DBS and dopaminergic medication on cortical somatosensory processing in PD patients despite consistent ameliorating effects of both treatments on PD motor symptoms.SIGNIFICANCE: The differentiated effect suggests differences in the effect mechanisms of the two treatments.

KW - Journal Article

U2 - 10.1016/j.clinph.2017.04.014

DO - 10.1016/j.clinph.2017.04.014

M3 - Journal article

C2 - 28570866

VL - 128

SP - 1327

EP - 1336

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 7

ER -