Differential Modulating Effect of MoS2 on Amyloid Peptide Assemblies

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  • Jie Wang, Institute for Advanced Materials, and School of Materials Science and Engineering, Jiangsu University
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  • Lei Liu, Institute for Advanced Materials, and School of Materials Science and Engineering, Jiangsu University
  • ,
  • Daohan Ge, Jiangsu University
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  • Hongxing Zhang, Institute for Advanced Materials, and School of Materials Science and Engineering, Jiangsu University
  • ,
  • Yonghai Feng, Institute for Advanced Materials, and School of Materials Science and Engineering, Jiangsu University
  • ,
  • Yibang Zhang, Zhang Department of Pharmaceutics
  • ,
  • Menglin Chen
  • MD Dong

The abnormal fibrillogenesis of amyloid peptides such as amyloid fibril and senior amyloid plaques, is associated with the pathogenesis of many amyloid diseases. Hence, modulation of amyloid assemblies is related to the possible pathogenesis of some diseases. Some two-dimensional nanomaterials, that is, graphene oxide, tungsten disulfide, exhibit strong modulation effects on the amyloid fibrillogenesis. Herein, the modulation effect of molybdenum disulfide on two amyloid peptide assemblies based on the label-free techniques is presented, including quartz crystal microbalance (QCM), AFM, and CD spectroscopy. MoS 2 presents different modulating effects on the assembly of amyloid-β peptide (33–42) [Aβ (33–42)] and amylin (20–29), mainly owing to the distinct affinity between amyloid peptides and MoS 2. This is to our knowledge the first report of MoS 2 as a modulator for amyloid aggregation. It enriches the variety of 2D nanomodulators of amyloid fibrillogenesis and explains the mechanism for the self-assembly of amyloid peptides, and expands the applications of MoS 2 in biology.

Original languageEnglish
JournalChemistry: A European Journal
Volume24
Issue14
Pages (from-to)3397-3402
Number of pages6
ISSN0947-6539
DOIs
Publication statusPublished - Mar 2018

    Research areas

  • amyloid peptides, biophysics, fibrillogenesis, modulating assembly, molybdenum disulfide, FIBRILLATION, T FLUORESCENCE ASSAY, FIBRILS, INHIBITION, ALZHEIMERS-DISEASE, NANOMATERIALS, Peptide Fragments, Quartz Crystal Microbalance Techniques, Nanostructures, Amyloid beta-Peptides/chemistry, Plaque, Amyloid/chemistry, Molybdenum/metabolism, Islet Amyloid Polypeptide, Graphite, Amyloid, Amyloidosis, Disulfides/metabolism

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