Dietary restriction reduces age-related degeneration of stria vascularis in the inner ear of the rat

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Dietary restriction reduces age-related degeneration of stria vascularis in the inner ear of the rat. / Mannström, Paula; Ulfhake, Brun; Kirkegaard, Mette; Ulfendahl, Mats.

In: Experimental Gerontology, Vol. 48, No. 11, 11.2013, p. 1173-9.

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Mannström, P, Ulfhake, B, Kirkegaard, M & Ulfendahl, M 2013, 'Dietary restriction reduces age-related degeneration of stria vascularis in the inner ear of the rat', Experimental Gerontology, vol. 48, no. 11, pp. 1173-9. https://doi.org/10.1016/j.exger.2013.07.004

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Mannström, Paula ; Ulfhake, Brun ; Kirkegaard, Mette ; Ulfendahl, Mats. / Dietary restriction reduces age-related degeneration of stria vascularis in the inner ear of the rat. In: Experimental Gerontology. 2013 ; Vol. 48, No. 11. pp. 1173-9.

Bibtex

@article{8f268d3fc6fb4b90b8bfa5abef5ea9de,
title = "Dietary restriction reduces age-related degeneration of stria vascularis in the inner ear of the rat",
abstract = "We report here beneficial effects of life-long dietary restriction on the progression of age-associated cochlear degeneration in female Sprague-Dawley rats. Thirty-month old rats on a 70{\%} dietary restriction were compared to ad libitum fed age-matched rats, and three-month old adult rats. As expected, aged dietary restricted rats displayed about 20{\%} higher survival rate than age-matched rats fed ad libitum. This difference was reflected also in the auditory system. In the dietary restricted group, 73{\%} of the subjects had preserved auditory reflexes (Preyer), and only modest degeneration of the stria vascularis of the inner ear was observed. In contrast, aged ad libitum fed animals, of which only 15{\%} had detectable Preyer reflexes, showed a marked thinning, cellular degeneration and loss of cell processes in the stria vascularis. The extent of loss of sensory hair cells (~24{\%}) was similar in both the aged groups, and neither group showed a significant reduction in the number of spiral ganglion neurons across adult life-span. The observations thus demonstrate that dietary restriction delays age-related degradation of the auditory system. The results provide further insights into the mechanisms of strial presbycusis.",
keywords = "Aging, Animals, Caloric Restriction, Disease Models, Animal, Female, Microscopy, Electron, Transmission, Neurons, Presbycusis, Rats, Rats, Sprague-Dawley, Reflex, Acoustic, Spiral Ganglion, Stria Vascularis",
author = "Paula Mannstr{\"o}m and Brun Ulfhake and Mette Kirkegaard and Mats Ulfendahl",
note = "{\circledC} 2013. Published by Elsevier Inc. All rights reserved.",
year = "2013",
month = "11",
doi = "10.1016/j.exger.2013.07.004",
language = "English",
volume = "48",
pages = "1173--9",
journal = "Experimental Gerontology",
issn = "0531-5565",
publisher = "Elsevier Inc",
number = "11",

}

RIS

TY - JOUR

T1 - Dietary restriction reduces age-related degeneration of stria vascularis in the inner ear of the rat

AU - Mannström, Paula

AU - Ulfhake, Brun

AU - Kirkegaard, Mette

AU - Ulfendahl, Mats

N1 - © 2013. Published by Elsevier Inc. All rights reserved.

PY - 2013/11

Y1 - 2013/11

N2 - We report here beneficial effects of life-long dietary restriction on the progression of age-associated cochlear degeneration in female Sprague-Dawley rats. Thirty-month old rats on a 70% dietary restriction were compared to ad libitum fed age-matched rats, and three-month old adult rats. As expected, aged dietary restricted rats displayed about 20% higher survival rate than age-matched rats fed ad libitum. This difference was reflected also in the auditory system. In the dietary restricted group, 73% of the subjects had preserved auditory reflexes (Preyer), and only modest degeneration of the stria vascularis of the inner ear was observed. In contrast, aged ad libitum fed animals, of which only 15% had detectable Preyer reflexes, showed a marked thinning, cellular degeneration and loss of cell processes in the stria vascularis. The extent of loss of sensory hair cells (~24%) was similar in both the aged groups, and neither group showed a significant reduction in the number of spiral ganglion neurons across adult life-span. The observations thus demonstrate that dietary restriction delays age-related degradation of the auditory system. The results provide further insights into the mechanisms of strial presbycusis.

AB - We report here beneficial effects of life-long dietary restriction on the progression of age-associated cochlear degeneration in female Sprague-Dawley rats. Thirty-month old rats on a 70% dietary restriction were compared to ad libitum fed age-matched rats, and three-month old adult rats. As expected, aged dietary restricted rats displayed about 20% higher survival rate than age-matched rats fed ad libitum. This difference was reflected also in the auditory system. In the dietary restricted group, 73% of the subjects had preserved auditory reflexes (Preyer), and only modest degeneration of the stria vascularis of the inner ear was observed. In contrast, aged ad libitum fed animals, of which only 15% had detectable Preyer reflexes, showed a marked thinning, cellular degeneration and loss of cell processes in the stria vascularis. The extent of loss of sensory hair cells (~24%) was similar in both the aged groups, and neither group showed a significant reduction in the number of spiral ganglion neurons across adult life-span. The observations thus demonstrate that dietary restriction delays age-related degradation of the auditory system. The results provide further insights into the mechanisms of strial presbycusis.

KW - Aging

KW - Animals

KW - Caloric Restriction

KW - Disease Models, Animal

KW - Female

KW - Microscopy, Electron, Transmission

KW - Neurons

KW - Presbycusis

KW - Rats

KW - Rats, Sprague-Dawley

KW - Reflex, Acoustic

KW - Spiral Ganglion

KW - Stria Vascularis

U2 - 10.1016/j.exger.2013.07.004

DO - 10.1016/j.exger.2013.07.004

M3 - Journal article

VL - 48

SP - 1173

EP - 1179

JO - Experimental Gerontology

JF - Experimental Gerontology

SN - 0531-5565

IS - 11

ER -