Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

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  • Heleen Van Puyvelde, Ghent Univ Hosp, Ghent University Hospital, Ghent University, Dept Rheumatol, Research Foundation Flanders – FWO., International Agency for Research on Cancer, Lyon, France., Belgium
  • Nikos Papadimitriou, International Agency for Research on Cancer, Lyon, France., France
  • Joanna Clasen, Imperial Coll London, Imperial College London, Imperial Clin Trials Unit, United Kingdom
  • David Muller, Imperial Coll London, Imperial College London, Imperial Clin Trials Unit, United Kingdom
  • Carine Biessy, International Agency for Research on Cancer, Lyon, France., France
  • Pietro Ferrari, International Agency for Research on Cancer, Lyon, France.
  • ,
  • Jytte Halkjær, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., Denmark
  • Kim Overvad
  • Anne Tjønneland, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., University of Copenhagen, Denmark
  • Renée T Fortner, CCU Neuropathology, German Consortium for Translational Cancer Research, German Cancer Research Center, Heidelberg, Germany., Germany
  • Verena Katzke, CCU Neuropathology, German Consortium for Translational Cancer Research, German Cancer Research Center, Heidelberg, Germany., Germany
  • Matthias B Schulze, German Institute of Human Nutrition Potsdam-Rehbruecke, Potsdam, Germany., University of Potsdam, Germany
  • Paolo Chiodini, University of Campania Luigi Vanvitelli, Italy
  • Giovanna Masala, Prevention and Clinical Network - ISPRO, Italy
  • Valeria Pala, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Venezian 1, 20133, Milan, Italy., Italy
  • Carlotta Sacerdote, Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Centre for Cancer Prevention (CPO), Turin, Italy
  • Rosario Tumino, Cancer Registry and Histopathology Department, 'Civic - M.P.Arezzo' Hospital, Italy., Italy
  • Marije F Bakker, Univ Utrecht, Utrecht University Medical Center, Utrecht University, Univ Med Ctr Utrecht, Regenerat Med Ctr, Netherlands
  • Antonio Agudo, Cancer Epidemiology Research Program, Unit of Nutrition and Cancer, Institut Català d'Oncologa, L'Hospitalet de Llobregat, Barcelona, Spain
  • Eva Ardanaz, Navarra Inst Hlth Res, IdiSNA, CIBER Epidemiology and Public Health CIBERESP, Navarra Public Health Institute, Spain
  • María Dolores Chirlaque López, CIBER Epidemiology and Public Health CIBERESP, Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain., Spain
  • Maria-Jose Sánchez, CIBER Epidemiology and Public Health CIBERESP, Escuela Andaluza de Salud Pública (EASP), Granada, Instituto de Investigación Biosanitaria ibs, Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
  • Ulrika Ericson, Diabetes and Cardiovascular Disease, Genetic Epidemiology, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
  • Björn Gylling, Umeå Universitet, Sweden
  • Therese Karlsson, Univ Gothenburg, University of Gothenburg, Gothenburg Global Biodivers Ctr, Sweden
  • Jonas Manjer, Department of Surgery, Lund University, Skåne University Hospital, Malmö, Sweden, Sweden
  • Julie A Schmidt, Nuffield Department of Population Health, University of Oxford, Oxford, England., United Kingdom
  • Geneviève Nicolas, International Agency for Research on Cancer, France
  • Corinne Casagrande, International Agency for Research on Cancer, France
  • Elisabete Weiderpass, Office of the Director, International Agency For Research On Cancer., France
  • Alicia K Heath, Imperial Coll London, Imperial College London, Imperial Clin Trials Unit, United Kingdom
  • Lode Godderis, KU Leuven, IDEWE Occupational Services
  • ,
  • Koen Van Herck, Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Belgium
  • Dirk De Bacquer, Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Belgium
  • Marc J Gunter, International Agency for Research on Cancer
  • ,
  • Inge Huybrechts, International Agency for Research on Cancer, France

(1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results: 318,686 pre- and postmenopausal women were followed between enrolment in 1992-2000 and December 2013-December 2015. Dietary MGD intakes were estimated at baseline through food-frequency questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary intake of MGDs, measured both as a calculated score based on their sum and individually, and BC risk. Subgroup analyses were performed by hormone receptor status, menopausal status, and level of alcohol intake. During a mean follow-up time of 14.1 years, 13,320 women with malignant BC were identified. No associations were found between dietary intakes of the MGD score or individual MGDs and BC risk. However, a potential U-shaped relationship was observed between dietary folate intake and overall BC risk, suggesting an inverse association for intakes up to 350 µg/day compared to a reference intake of 205 µg/day. No statistically significant differences in the associations were observed by hormone receptor status, menopausal status, or level of alcohol intake; (4) Conclusions: There was no strong evidence for an association between MGDs involved in one-carbon metabolism and BC risk. However, a potential U-shaped trend was suggested for dietary folate intake and BC risk. Further research is needed to clarify this association.

Original languageEnglish
Article number1843
JournalNutrients
Volume13
Issue6
Number of pages15
ISSN2072-6643
DOIs
Publication statusPublished - Jun 2021

    Research areas

  • EPIC, betaine, breast cancer, choline, folate, methionine

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