Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

S G Yammine; I Huybrechts; C Biessy; L Dossus; S Panico; M J Sánchez; V Benetou; R Turzanski-Fortner; V Katzke; A Idahl; G Skeie; K Standahl Olsen; A Tjønneland; J Halkjaer; S Colorado-Yohar; A K Heath; E Sonestedt; H Sartor; M B Schulze; D Palli; M Crous-Bou; A Dorronsoro; K Overvad; A Barricarte Gurrea; G Severi; R C H Vermeulen; T M Sandanger; R C Travis; T Key; P Amiano; B Van Guelpen; M Johansson; M Sund; R Tumino; N Wareham; C Sacerdote; V Krogh; P Brennan; E Riboli; E Weiderpass; M J Gunter; V Chajès

doi:10.1186/s12885-023-10611-0

Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

S G Yammine^*, I Huybrechts, C Biessy, L Dossus, S Panico, M J Sánchez, V Benetou, R Turzanski-Fortner, V Katzke, A Idahl, G Skeie, K Standahl Olsen, A Tjønneland, J Halkjaer, S Colorado-Yohar, A K Heath, E Sonestedt, H Sartor, M B Schulze, D PalliM Crous-Bou, A Dorronsoro, K Overvad, A Barricarte Gurrea, G Severi, R C H Vermeulen, T M Sandanger, R C Travis, T Key, P Amiano, B Van Guelpen, M Johansson, M Sund, R Tumino, N Wareham, C Sacerdote, V Krogh, P Brennan, E Riboli, E Weiderpass, M J Gunter, V Chajès

^*Corresponding author for this work

Department of Public Health - Department of Epidemiology

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

1 Citation (Scopus)

Abstract

BACKGROUND: Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).

METHODS: This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.

RESULTS: Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintileQ5-Q1=0.77, 95% CI = 0.64; 0.92, ptrend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk.

CONCLUSION: Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.

Original language	English
Article number	159
Journal	BMC Cancer
Volume	23
Issue	1
Number of pages	12
ISSN	1471-2407
DOIs	https://doi.org/10.1186/s12885-023-10611-0
Publication status	Published - Dec 2023

Keywords

Fatty acids
Endometrial cancer
Epidemiology
Diet

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Yammine, S. G., Huybrechts, I., Biessy, C., Dossus, L., Panico, S., Sánchez, M. J., Benetou, V., Turzanski-Fortner, R., Katzke, V., Idahl, A., Skeie, G., Olsen, K. S., Tjønneland, A., Halkjaer, J., Colorado-Yohar, S., Heath, A. K., Sonestedt, E., Sartor, H., Schulze, M. B., ... Chajès, V. (2023). Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition. BMC Cancer, 23(1), Article 159. https://doi.org/10.1186/s12885-023-10611-0

@article{415531e04a824d60b152051a10651263,

title = "Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition",

abstract = "BACKGROUND: Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).METHODS: This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.RESULTS: Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintileQ5-Q1=0.77, 95% CI = 0.64; 0.92, ptrend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk.CONCLUSION: Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.",

keywords = "Fatty acids, Endometrial cancer, Epidemiology, Diet",

author = "Yammine, {S G} and I Huybrechts and C Biessy and L Dossus and S Panico and S{\'a}nchez, {M J} and V Benetou and R Turzanski-Fortner and V Katzke and A Idahl and G Skeie and Olsen, {K Standahl} and A Tj{\o}nneland and J Halkjaer and S Colorado-Yohar and Heath, {A K} and E Sonestedt and H Sartor and Schulze, {M B} and D Palli and M Crous-Bou and A Dorronsoro and K Overvad and Gurrea, {A Barricarte} and G Severi and Vermeulen, {R C H} and Sandanger, {T M} and Travis, {R C} and T Key and P Amiano and {Van Guelpen}, B and M Johansson and M Sund and R Tumino and N Wareham and C Sacerdote and V Krogh and P Brennan and E Riboli and E Weiderpass and Gunter, {M J} and V Chaj{\`e}s",

year = "2023",

month = dec,

doi = "10.1186/s12885-023-10611-0",

language = "English",

volume = "23",

journal = "BMC Cancer",

issn = "1471-2407",

publisher = "BioMed Central Ltd.",

number = "1",

}

Yammine, SG, Huybrechts, I, Biessy, C, Dossus, L, Panico, S, Sánchez, MJ, Benetou, V, Turzanski-Fortner, R, Katzke, V, Idahl, A, Skeie, G, Olsen, KS, Tjønneland, A, Halkjaer, J, Colorado-Yohar, S, Heath, AK, Sonestedt, E, Sartor, H, Schulze, MB, Palli, D, Crous-Bou, M, Dorronsoro, A, Overvad, K, Gurrea, AB, Severi, G, Vermeulen, RCH, Sandanger, TM, Travis, RC, Key, T, Amiano, P, Van Guelpen, B, Johansson, M, Sund, M, Tumino, R, Wareham, N, Sacerdote, C, Krogh, V, Brennan, P, Riboli, E, Weiderpass, E, Gunter, MJ & Chajès, V 2023, 'Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition', BMC Cancer, vol. 23, no. 1, 159. https://doi.org/10.1186/s12885-023-10611-0

TY - JOUR

T1 - Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

AU - Yammine, S G

AU - Huybrechts, I

AU - Biessy, C

AU - Dossus, L

AU - Panico, S

AU - Sánchez, M J

AU - Benetou, V

AU - Turzanski-Fortner, R

AU - Katzke, V

AU - Idahl, A

AU - Skeie, G

AU - Olsen, K Standahl

AU - Tjønneland, A

AU - Halkjaer, J

AU - Colorado-Yohar, S

AU - Heath, A K

AU - Sonestedt, E

AU - Sartor, H

AU - Schulze, M B

AU - Palli, D

AU - Crous-Bou, M

AU - Dorronsoro, A

AU - Overvad, K

AU - Gurrea, A Barricarte

AU - Severi, G

AU - Vermeulen, R C H

AU - Sandanger, T M

AU - Travis, R C

AU - Key, T

AU - Amiano, P

AU - Van Guelpen, B

AU - Johansson, M

AU - Sund, M

AU - Tumino, R

AU - Wareham, N

AU - Sacerdote, C

AU - Krogh, V

AU - Brennan, P

AU - Riboli, E

AU - Weiderpass, E

AU - Gunter, M J

AU - Chajès, V

PY - 2023/12

Y1 - 2023/12

N2 - BACKGROUND: Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).METHODS: This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.RESULTS: Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintileQ5-Q1=0.77, 95% CI = 0.64; 0.92, ptrend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk.CONCLUSION: Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.

AB - BACKGROUND: Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).METHODS: This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.RESULTS: Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintileQ5-Q1=0.77, 95% CI = 0.64; 0.92, ptrend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk.CONCLUSION: Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.

KW - Fatty acids

KW - Endometrial cancer

KW - Epidemiology

KW - Diet

UR - http://www.scopus.com/inward/record.url?scp=85148260026&partnerID=8YFLogxK

U2 - 10.1186/s12885-023-10611-0

DO - 10.1186/s12885-023-10611-0

M3 - Journal article

C2 - 36797668

SN - 1471-2407

VL - 23

JO - BMC Cancer

JF - BMC Cancer

IS - 1

M1 - 159

ER -

Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

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