Diagnostic and prognostic value of mannan-binding lectin associated protein (MAp19) for functionally relevant coronary artery disease

Ganna Isayeva*, Klara Rumora, Eliska Potlukova, Jan-Philipp Leibfarth, Ibrahim Schäfer, Zsofia Bartha, Michael J Zellweger, Marten Trendelenburg, Trine Korsgaard Hejlesen, Annette Gudmann Hansen, Steffen Thiel, Christian Mueller

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

BACKGROUND: This study aimed to evaluate the diagnostic and prognostic potential of MAp19, a regulating component of the lectin pathway of the complement system, in patients with suspected functionally relevant coronary artery disease (fCAD) as well as the determinants of MAp19 levels.

METHODS: The presence of fCAD was adjudicated using myocardial perfusion imaging with single-photon emission tomography and, where available, coronary angiography. MAp19 levels were measured in participants at rest, at peak stress tests, and two hours after the stress. The study also tracked major cardiovascular events, including non-fatal myocardial infarction and cardiovascular death, over a five-year follow-up period.

RESULTS: Among the 1,571 patients analyzed (32.3 % women), fCAD was identified in 462 individuals (29.4 %). MAp19 demonstrated no diagnostic significance, yielding an area under the curve (AUC) of 0.51 (0.47-0.55). Throughout the five-year follow-up, 107 patients (6.8 %) experienced non-fatal myocardial infarctions, 99 (6.3 %) had cardiovascular death, 194 (12.3 %) experienced all cause death and 50 (3.1 %) suffered a stroke. Cox and Kaplan-Meier analysis confirmed prognostic value of MAp19 for myocardial infarction, but not for cardiovascular death. Significant increases in the concentration of MAp19 were observed during bicycle (p = 0.001) and combined stress tests (p = 0.001).

CONCLUSION: MAp19 demonstrated an association with the risk of myocardial infarction. Increases in MAp19 concentration were observed during bicycle and combined stress-tests.

Original languageEnglish
Article number119668
JournalClinica Chimica Acta
Volume558
ISSN0009-8981
DOIs
Publication statusPublished - 15 May 2024

Keywords

  • Functionally relevant coronary artery disease
  • MAp19
  • Mannan-binding lectin associated protein
  • Myocardial infarction
  • Prognosis
  • Stress-test
  • The complement system

Fingerprint

Dive into the research topics of 'Diagnostic and prognostic value of mannan-binding lectin associated protein (MAp19) for functionally relevant coronary artery disease'. Together they form a unique fingerprint.

Cite this