Diagnosed eating disorders in Danish registers - incidence, prevalence, mortality, and polygenic risk

Janne Tidselbak Larsen; Zeynep Yilmaz; Cynthia M Bulik; Clara Albiñana; Bjarni Jóhann Vilhjálmsson; Preben Bo Mortensen; Liselotte Vogdrup Petersen

doi:10.1016/j.psychres.2024.115927

Diagnosed eating disorders in Danish registers - incidence, prevalence, mortality, and polygenic risk

Janne Tidselbak Larsen, Zeynep Yilmaz, Cynthia M Bulik, Clara Albiñana, Bjarni Jóhann Vilhjálmsson, Preben Bo Mortensen, Liselotte Vogdrup Petersen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2 Citations (Scopus)

Abstract

Eating disorders are a group of severe and potentially enduring psychiatric disorders associated with increased mortality. Compared to other severe mental illnesses, they have received relatively limited research attention. Epidemiological studies often only report relative measures despite these being difficult to interpret having limited practical use. The aims of this study were to evaluate the incidence and prevalence of diagnosed anorexia nervosa (AN), bulimia nervosa, and eating disorder not otherwise specified recorded in Danish hospital registers and estimate both relative and absolute measures of subsequent mortality - both all-cause and cause-specific in a general nationwide population of 1,667,374 individuals. In a smaller, genetically informed case-cohort sample, the prediction of polygenic scores for AN, body fat percentage, and body mass index on AN prevalence and severity was estimated. Despite males being less likely to be diagnosed with an eating disorder, those that do have significantly increased rates of mortality. AN prevalence was highest for individuals with high AN and low body fat percentage/body mass index polygenic scores.

Original language	English
Article number	115927
Journal	Psychiatry Research
Volume	337
Pages (from-to)	115927
ISSN	0165-1781
DOIs	https://doi.org/10.1016/j.psychres.2024.115927
Publication status	E-pub ahead of print - 27 Apr 2024

Keywords

Anorexia nervosa
Bulimia nervosa
EDNOS
Eating disorder not otherwise specified
Epidemiology
Sex differences

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10.1016/j.psychres.2024.115927

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title = "Diagnosed eating disorders in Danish registers - incidence, prevalence, mortality, and polygenic risk",

abstract = "Eating disorders are a group of severe and potentially enduring psychiatric disorders associated with increased mortality. Compared to other severe mental illnesses, they have received relatively limited research attention. Epidemiological studies often only report relative measures despite these being difficult to interpret having limited practical use. The aims of this study were to evaluate the incidence and prevalence of diagnosed anorexia nervosa (AN), bulimia nervosa, and eating disorder not otherwise specified recorded in Danish hospital registers and estimate both relative and absolute measures of subsequent mortality - both all-cause and cause-specific in a general nationwide population of 1,667,374 individuals. In a smaller, genetically informed case-cohort sample, the prediction of polygenic scores for AN, body fat percentage, and body mass index on AN prevalence and severity was estimated. Despite males being less likely to be diagnosed with an eating disorder, those that do have significantly increased rates of mortality. AN prevalence was highest for individuals with high AN and low body fat percentage/body mass index polygenic scores.",

keywords = "Anorexia nervosa, Bulimia nervosa, EDNOS, Eating disorder not otherwise specified, Epidemiology, Sex differences",

author = "Larsen, {Janne Tidselbak} and Zeynep Yilmaz and Bulik, {Cynthia M} and Clara Albi{\~n}ana and Vilhj{\'a}lmsson, {Bjarni J{\'o}hann} and Mortensen, {Preben Bo} and Petersen, {Liselotte Vogdrup}",

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doi = "10.1016/j.psychres.2024.115927",

language = "English",

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Diagnosed eating disorders in Danish registers - incidence, prevalence, mortality, and polygenic risk. / Larsen, Janne Tidselbak ; Yilmaz, Zeynep; Bulik, Cynthia M et al.
In: Psychiatry Research, Vol. 337, 115927, 27.04.2024, p. 115927.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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AU - Larsen, Janne Tidselbak

AU - Yilmaz, Zeynep

AU - Bulik, Cynthia M

AU - Albiñana, Clara

AU - Vilhjálmsson, Bjarni Jóhann

AU - Mortensen, Preben Bo

AU - Petersen, Liselotte Vogdrup

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Diagnosed eating disorders in Danish registers - incidence, prevalence, mortality, and polygenic risk

Abstract

Keywords

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