Diabetic polyneuropathy and pain, prevalence, and patient characteristics: a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes

Sandra Sif Gylfadottir; Diana Hedevang Christensen; Sia Kromann Nicolaisen; Henning Andersen; Brian Christopher Callaghan; Mustapha Itani; Karolina Snopek Khan; Alexander Gramm Kristensen; Jens Steen Nielsen; Søren Hein Sindrup; Niels Trolle Andersen; Troels Staehelin Jensen; Reimar Wernich Thomsen; Nanna Brix Finnerup

doi:10.1097/j.pain.0000000000001744

Diabetic polyneuropathy and pain, prevalence, and patient characteristics: a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes

Sandra Sif Gylfadottir, Diana Hedevang Christensen, Sia Kromann Nicolaisen, Henning Andersen, Brian Christopher Callaghan, Mustapha Itani, Karolina Snopek Khan, Alexander Gramm Kristensen, Jens Steen Nielsen, Søren Hein Sindrup, Niels Trolle Andersen, Troels Staehelin Jensen, Reimar Wernich Thomsen, Nanna Brix Finnerup

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Abstract

Most studies of diabetic polyneuropathy (DPN) and painful DPN are conducted in persons with longstanding diabetes. This cross-sectional study aimed to estimate the prevalence of DPN and painful DPN, important risk factors, and the association with mental health in recently diagnosed type 2 diabetes. A total of 5,514 (82%) patients (median diabetes duration 4.6 years) enrolled in the Danish Centre for Strategic Research in Type 2 Diabetes cohort responded to a detailed questionnaire on neuropathy and pain. A score ≥ 4 on the MNSI questionnaire determined possible DPN whereas pain presence in both feet together with a score ≥ 3 on the DN4 questionnaire determined possible painful DPN. The prevalence of possible DPN and possible painful DPN was 18% and 10%, respectively. Female sex, age, diabetes duration, BMI, and smoking were associated with possible DPN, whereas only smoking showed a clear association with possible painful DPN (OR 1.52 [95% CI: 1.20; 1.93]). Possible DPN and painful DPN were independently and additively associated with lower quality-of-life, poorer sleep, and symptoms of depression and anxiety. Possible DPN itself had greater impact on mental health than neuropathic pain. This large study emphasizes the importance of careful screening for DPN and pain early in the course of type 2 diabetes.

Original language	English
Journal	Pain
Volume	161
Issue	3
Pages (from-to)	574-583
Number of pages	10
ISSN	0304-3959
DOIs	https://doi.org/10.1097/j.pain.0000000000001744
Publication status	Published - 2020

Keywords

COMPLICATIONS
DEPRESSION
EMOTIONAL DISTRESS
EPIDEMIOLOGY
Mental health
NEUROPATHIC PAIN
Neuropathic pain
PERIPHERAL NEUROPATHY
PHENOTYPE
POPULATION
Painful diabetic polyneuropathy
Patient characteristics
Polyneuropathy
Prevalence
QUALITY-OF-LIFE
Quality of life
RISK-FACTORS

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Diabetic_polyneuropathy_and_pain,_prevalence,_and.14Final published version, 689 KBLicence: CC BY-NC-ND

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Gylfadottir, S. S., Christensen, D. H., Nicolaisen, S. K., Andersen, H., Callaghan, B. C., Itani, M., Khan, K. S., Kristensen, A. G., Nielsen, J. S., Sindrup, S. H., Andersen, N. T., Jensen, T. S., Thomsen, R. W., & Finnerup, N. B. (2020). Diabetic polyneuropathy and pain, prevalence, and patient characteristics: a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes. Pain, 161(3), 574-583. https://doi.org/10.1097/j.pain.0000000000001744

@article{5538949114264123ba305ff636a10345,

title = "Diabetic polyneuropathy and pain, prevalence, and patient characteristics: a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes",

abstract = "Most studies of diabetic polyneuropathy (DPN) and painful DPN are conducted in persons with longstanding diabetes. This cross-sectional study aimed to estimate the prevalence of DPN and painful DPN, important risk factors, and the association with mental health in recently diagnosed type 2 diabetes. A total of 5,514 (82%) patients (median diabetes duration 4.6 years) enrolled in the Danish Centre for Strategic Research in Type 2 Diabetes cohort responded to a detailed questionnaire on neuropathy and pain. A score ≥ 4 on the MNSI questionnaire determined possible DPN whereas pain presence in both feet together with a score ≥ 3 on the DN4 questionnaire determined possible painful DPN. The prevalence of possible DPN and possible painful DPN was 18% and 10%, respectively. Female sex, age, diabetes duration, BMI, and smoking were associated with possible DPN, whereas only smoking showed a clear association with possible painful DPN (OR 1.52 [95% CI: 1.20; 1.93]). Possible DPN and painful DPN were independently and additively associated with lower quality-of-life, poorer sleep, and symptoms of depression and anxiety. Possible DPN itself had greater impact on mental health than neuropathic pain. This large study emphasizes the importance of careful screening for DPN and pain early in the course of type 2 diabetes.",

keywords = "COMPLICATIONS, DEPRESSION, EMOTIONAL DISTRESS, EPIDEMIOLOGY, Mental health, NEUROPATHIC PAIN, Neuropathic pain, PERIPHERAL NEUROPATHY, PHENOTYPE, POPULATION, Painful diabetic polyneuropathy, Patient characteristics, Polyneuropathy, Prevalence, QUALITY-OF-LIFE, Quality of life, RISK-FACTORS",

author = "Gylfadottir, {Sandra Sif} and Christensen, {Diana Hedevang} and Nicolaisen, {Sia Kromann} and Henning Andersen and Callaghan, {Brian Christopher} and Mustapha Itani and Khan, {Karolina Snopek} and Kristensen, {Alexander Gramm} and Nielsen, {Jens Steen} and Sindrup, {S{\o}ren Hein} and Andersen, {Niels Trolle} and Jensen, {Troels Staehelin} and Thomsen, {Reimar Wernich} and Finnerup, {Nanna Brix}",

year = "2020",

doi = "10.1097/j.pain.0000000000001744",

language = "English",

volume = "161",

pages = "574--583",

journal = "Pain",

issn = "0304-3959",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

Gylfadottir, SS , Christensen, DH , Nicolaisen, SK , Andersen, H, Callaghan, BC, Itani, M, Khan, KS , Kristensen, AG, Nielsen, JS, Sindrup, SH, Andersen, NT , Jensen, TS , Thomsen, RW & Finnerup, NB 2020, 'Diabetic polyneuropathy and pain, prevalence, and patient characteristics: a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes', Pain, vol. 161, no. 3, pp. 574-583. https://doi.org/10.1097/j.pain.0000000000001744

Diabetic polyneuropathy and pain, prevalence, and patient characteristics: a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes. / Gylfadottir, Sandra Sif ; Christensen, Diana Hedevang ; Nicolaisen, Sia Kromann et al.
In: Pain, Vol. 161, No. 3, 2020, p. 574-583.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Diabetic polyneuropathy and pain, prevalence, and patient characteristics

T2 - a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes

AU - Gylfadottir, Sandra Sif

AU - Christensen, Diana Hedevang

AU - Nicolaisen, Sia Kromann

AU - Andersen, Henning

AU - Callaghan, Brian Christopher

AU - Itani, Mustapha

AU - Khan, Karolina Snopek

AU - Kristensen, Alexander Gramm

AU - Nielsen, Jens Steen

AU - Sindrup, Søren Hein

AU - Andersen, Niels Trolle

AU - Jensen, Troels Staehelin

AU - Thomsen, Reimar Wernich

AU - Finnerup, Nanna Brix

PY - 2020

Y1 - 2020

N2 - Most studies of diabetic polyneuropathy (DPN) and painful DPN are conducted in persons with longstanding diabetes. This cross-sectional study aimed to estimate the prevalence of DPN and painful DPN, important risk factors, and the association with mental health in recently diagnosed type 2 diabetes. A total of 5,514 (82%) patients (median diabetes duration 4.6 years) enrolled in the Danish Centre for Strategic Research in Type 2 Diabetes cohort responded to a detailed questionnaire on neuropathy and pain. A score ≥ 4 on the MNSI questionnaire determined possible DPN whereas pain presence in both feet together with a score ≥ 3 on the DN4 questionnaire determined possible painful DPN. The prevalence of possible DPN and possible painful DPN was 18% and 10%, respectively. Female sex, age, diabetes duration, BMI, and smoking were associated with possible DPN, whereas only smoking showed a clear association with possible painful DPN (OR 1.52 [95% CI: 1.20; 1.93]). Possible DPN and painful DPN were independently and additively associated with lower quality-of-life, poorer sleep, and symptoms of depression and anxiety. Possible DPN itself had greater impact on mental health than neuropathic pain. This large study emphasizes the importance of careful screening for DPN and pain early in the course of type 2 diabetes.

AB - Most studies of diabetic polyneuropathy (DPN) and painful DPN are conducted in persons with longstanding diabetes. This cross-sectional study aimed to estimate the prevalence of DPN and painful DPN, important risk factors, and the association with mental health in recently diagnosed type 2 diabetes. A total of 5,514 (82%) patients (median diabetes duration 4.6 years) enrolled in the Danish Centre for Strategic Research in Type 2 Diabetes cohort responded to a detailed questionnaire on neuropathy and pain. A score ≥ 4 on the MNSI questionnaire determined possible DPN whereas pain presence in both feet together with a score ≥ 3 on the DN4 questionnaire determined possible painful DPN. The prevalence of possible DPN and possible painful DPN was 18% and 10%, respectively. Female sex, age, diabetes duration, BMI, and smoking were associated with possible DPN, whereas only smoking showed a clear association with possible painful DPN (OR 1.52 [95% CI: 1.20; 1.93]). Possible DPN and painful DPN were independently and additively associated with lower quality-of-life, poorer sleep, and symptoms of depression and anxiety. Possible DPN itself had greater impact on mental health than neuropathic pain. This large study emphasizes the importance of careful screening for DPN and pain early in the course of type 2 diabetes.

KW - COMPLICATIONS

KW - DEPRESSION

KW - EMOTIONAL DISTRESS

KW - EPIDEMIOLOGY

KW - Mental health

KW - NEUROPATHIC PAIN

KW - Neuropathic pain

KW - PERIPHERAL NEUROPATHY

KW - PHENOTYPE

KW - POPULATION

KW - Painful diabetic polyneuropathy

KW - Patient characteristics

KW - Polyneuropathy

KW - Prevalence

KW - QUALITY-OF-LIFE

KW - Quality of life

KW - RISK-FACTORS

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U2 - 10.1097/j.pain.0000000000001744

DO - 10.1097/j.pain.0000000000001744

M3 - Journal article

C2 - 31693539

SN - 0304-3959

VL - 161

SP - 574

EP - 583

JO - Pain

JF - Pain

IS - 3

ER -

Diabetic polyneuropathy and pain, prevalence, and patient characteristics: a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes

Abstract

Keywords

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