Developmental language disorder – heritability and genetic correlations with other disorders affecting language

Ron Nudel; Rikke Vang Chrsitensen; Nelli Kalnak; Mischa Lundberg; Michael Schwinn; Erik Sørensen; Christina Mikkelsen; Janna Nissen; Lea Arregui Nordahl Christoffersen; Bertram Dalskov Kjerulff; Thomas Folkmann Hansen; Kristoffer Sølvsten Burgdorf; DBDS Genomic Consortium

doi:10.1016/j.psychres.2024.116212

Developmental language disorder – heritability and genetic correlations with other disorders affecting language

Ron Nudel^*, Rikke Vang Chrsitensen, Nelli Kalnak, Mischa Lundberg, Michael Schwinn, Erik Sørensen, Christina Mikkelsen, Janna Nissen, Lea Arregui Nordahl Christoffersen, Bertram Dalskov Kjerulff, Thomas Folkmann Hansen, Kristoffer Sølvsten Burgdorf, DBDS Genomic Consortium

^*Corresponding author for this work

Department of Clinical Medicine - Department of Clinical Immunology

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Developmental language disorder (DLD) is a neurodevelopmental disorder primarily affecting language in the absence of a known biomedical condition, which may have a large impact on a person's life and mental health. Family-based studies indicate a strong genetic component in DLD, but genetic studies of DLD are scarce. In this study we estimated the heritability of DLD and its genetic correlations with related disorders and traits in sample of >25,000 individuals from the Danish Blood Donor Study for whom we had both genotype data and questionnaire data on language disorder and language support. We estimated SNP-based heritabilities for DLD and genetic correlations with disorders which may involve spoken language deficits and traits related to spoken language. We found significant heritability estimates for DLD ranging from ∼27 % to ∼52 %, depending on the method used. We found no significant evidence for genetic correlation with the investigated disorders or traits, although the strongest effect was observed for a negative genetic correlation between DLD and nonword repetition ability. To our knowledge, this study reports the first significant heritability estimate for DLD from molecular genetic data.

Original language	English
Article number	116212
Journal	Psychiatry Research
Volume	342
ISSN	0165-1781
DOIs	https://doi.org/10.1016/j.psychres.2024.116212
Publication status	Published - Dec 2024

Keywords

Developmental language disorder
Genetic correlation
Heritability

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10.1016/j.psychres.2024.116212

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Nudel, R., Chrsitensen, R. V., Kalnak, N., Lundberg, M., Schwinn, M., Sørensen, E., Mikkelsen, C., Nissen, J., Christoffersen, L. A. N., Kjerulff, B. D., Hansen, T. F., Burgdorf, K. S., & DBDS Genomic Consortium (2024). Developmental language disorder – heritability and genetic correlations with other disorders affecting language. Psychiatry Research, 342, Article 116212. https://doi.org/10.1016/j.psychres.2024.116212

@article{e77e4dcab90444138b687e9c6929908f,

title = "Developmental language disorder – heritability and genetic correlations with other disorders affecting language",

abstract = "Developmental language disorder (DLD) is a neurodevelopmental disorder primarily affecting language in the absence of a known biomedical condition, which may have a large impact on a person's life and mental health. Family-based studies indicate a strong genetic component in DLD, but genetic studies of DLD are scarce. In this study we estimated the heritability of DLD and its genetic correlations with related disorders and traits in sample of >25,000 individuals from the Danish Blood Donor Study for whom we had both genotype data and questionnaire data on language disorder and language support. We estimated SNP-based heritabilities for DLD and genetic correlations with disorders which may involve spoken language deficits and traits related to spoken language. We found significant heritability estimates for DLD ranging from ∼27 % to ∼52 %, depending on the method used. We found no significant evidence for genetic correlation with the investigated disorders or traits, although the strongest effect was observed for a negative genetic correlation between DLD and nonword repetition ability. To our knowledge, this study reports the first significant heritability estimate for DLD from molecular genetic data.",

keywords = "Developmental language disorder, Genetic correlation, Heritability",

author = "Ron Nudel and Chrsitensen, {Rikke Vang} and Nelli Kalnak and Mischa Lundberg and Michael Schwinn and Erik S{\o}rensen and Christina Mikkelsen and Janna Nissen and Christoffersen, {Lea Arregui Nordahl} and Kjerulff, {Bertram Dalskov} and Hansen, {Thomas Folkmann} and Burgdorf, {Kristoffer S{\o}lvsten} and Karina Banasik and Jakob Bay and {Kj{\ae}rgaard Boldsen}, Jens and Thorsten Brodersen and S{\o}ren Brunak and Demur, {Alfonso Buil} and {Nordahl Christoffersen}, {Lea Arregui} and Maria Didriksen and Dinh, {Khoa Manh} and Joseph Dowsett and Christian Erikstrup and Bjarke Feenstra and Frank Geller and Daniel Gudbjartsson and Mikkelsen, {Dorte Helenius} and Lotte Hindhede and Henrik Hjalgrim and {von Stemann}, {Jakob Hjorth} and Jensen, {Bitten Aagaard} and Schork, {Andrew Joseph} and Kathrine Kaspersen and Mette Kongstad and Susan Mikkelsen and Mette Nyegaard and Ostrowski, {Sisse Rye} and Pedersen, {Ole Birger} and {Elgaard Quinn}, {Liam James} and {\TH}{\'o}runn Rafnar and Rohde, {Palle Duun} and Klaus Rostgaard and Kari Stefansson and Hreinn Stef{\'a}nsson and Th{\o}rner, {Lise Wegner} and Unnur {\TH}orsteinsd{\'o}ttir and Bruun, {Mie Topholm} and Henrik Ullum and Thomas Werge and Pedersen, {Ole Birger} and {DBDS Genomic Consortium}",

note = "Publisher Copyright: {\textcopyright} 2024",

year = "2024",

month = dec,

doi = "10.1016/j.psychres.2024.116212",

language = "English",

volume = "342",

journal = "Psychiatry Research",

issn = "0165-1781",

publisher = "Elsevier Ireland Ltd",

}

Nudel, R, Chrsitensen, RV, Kalnak, N, Lundberg, M, Schwinn, M, Sørensen, E, Mikkelsen, C, Nissen, J, Christoffersen, LAN, Kjerulff, BD, Hansen, TF, Burgdorf, KS & DBDS Genomic Consortium 2024, 'Developmental language disorder – heritability and genetic correlations with other disorders affecting language', Psychiatry Research, vol. 342, 116212. https://doi.org/10.1016/j.psychres.2024.116212

Developmental language disorder – heritability and genetic correlations with other disorders affecting language. / Nudel, Ron; Chrsitensen, Rikke Vang; Kalnak, Nelli et al.
In: Psychiatry Research, Vol. 342, 116212, 12.2024.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Developmental language disorder – heritability and genetic correlations with other disorders affecting language

AU - Nudel, Ron

AU - Chrsitensen, Rikke Vang

AU - Kalnak, Nelli

AU - Lundberg, Mischa

AU - Schwinn, Michael

AU - Sørensen, Erik

AU - Mikkelsen, Christina

AU - Nissen, Janna

AU - Christoffersen, Lea Arregui Nordahl

AU - Kjerulff, Bertram Dalskov

AU - Hansen, Thomas Folkmann

AU - Burgdorf, Kristoffer Sølvsten

AU - Banasik, Karina

AU - Bay, Jakob

AU - Kjærgaard Boldsen, Jens

AU - Brodersen, Thorsten

AU - Brunak, Søren

AU - Demur, Alfonso Buil

AU - Nordahl Christoffersen, Lea Arregui

AU - Didriksen, Maria

AU - Dinh, Khoa Manh

AU - Dowsett, Joseph

AU - Erikstrup, Christian

AU - Feenstra, Bjarke

AU - Geller, Frank

AU - Gudbjartsson, Daniel

AU - Mikkelsen, Dorte Helenius

AU - Hindhede, Lotte

AU - Hjalgrim, Henrik

AU - von Stemann, Jakob Hjorth

AU - Jensen, Bitten Aagaard

AU - Schork, Andrew Joseph

AU - Kaspersen, Kathrine

AU - Kongstad, Mette

AU - Mikkelsen, Susan

AU - Nyegaard, Mette

AU - Ostrowski, Sisse Rye

AU - Pedersen, Ole Birger

AU - Elgaard Quinn, Liam James

AU - Rafnar, Þórunn

AU - Rohde, Palle Duun

AU - Rostgaard, Klaus

AU - Stefansson, Kari

AU - Stefánsson, Hreinn

AU - Thørner, Lise Wegner

AU - Þorsteinsdóttir, Unnur

AU - Bruun, Mie Topholm

AU - Ullum, Henrik

AU - Werge, Thomas

AU - Pedersen, Ole Birger

AU - DBDS Genomic Consortium

PY - 2024/12

Y1 - 2024/12

N2 - Developmental language disorder (DLD) is a neurodevelopmental disorder primarily affecting language in the absence of a known biomedical condition, which may have a large impact on a person's life and mental health. Family-based studies indicate a strong genetic component in DLD, but genetic studies of DLD are scarce. In this study we estimated the heritability of DLD and its genetic correlations with related disorders and traits in sample of >25,000 individuals from the Danish Blood Donor Study for whom we had both genotype data and questionnaire data on language disorder and language support. We estimated SNP-based heritabilities for DLD and genetic correlations with disorders which may involve spoken language deficits and traits related to spoken language. We found significant heritability estimates for DLD ranging from ∼27 % to ∼52 %, depending on the method used. We found no significant evidence for genetic correlation with the investigated disorders or traits, although the strongest effect was observed for a negative genetic correlation between DLD and nonword repetition ability. To our knowledge, this study reports the first significant heritability estimate for DLD from molecular genetic data.

AB - Developmental language disorder (DLD) is a neurodevelopmental disorder primarily affecting language in the absence of a known biomedical condition, which may have a large impact on a person's life and mental health. Family-based studies indicate a strong genetic component in DLD, but genetic studies of DLD are scarce. In this study we estimated the heritability of DLD and its genetic correlations with related disorders and traits in sample of >25,000 individuals from the Danish Blood Donor Study for whom we had both genotype data and questionnaire data on language disorder and language support. We estimated SNP-based heritabilities for DLD and genetic correlations with disorders which may involve spoken language deficits and traits related to spoken language. We found significant heritability estimates for DLD ranging from ∼27 % to ∼52 %, depending on the method used. We found no significant evidence for genetic correlation with the investigated disorders or traits, although the strongest effect was observed for a negative genetic correlation between DLD and nonword repetition ability. To our knowledge, this study reports the first significant heritability estimate for DLD from molecular genetic data.

KW - Developmental language disorder

KW - Genetic correlation

KW - Heritability

UR - http://www.scopus.com/inward/record.url?scp=85205146733&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2024.116212

DO - 10.1016/j.psychres.2024.116212

M3 - Journal article

C2 - 39348781

AN - SCOPUS:85205146733

SN - 0165-1781

VL - 342

JO - Psychiatry Research

JF - Psychiatry Research

M1 - 116212

ER -

Developmental language disorder – heritability and genetic correlations with other disorders affecting language

Abstract

Keywords

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