Development of heart failure in patients with rheumatoid arthritis: A Danish population-based study

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OBJECTIVES: To investigate the incidence of heart failure (HF) and ischemic heart disease (IHD) in different time-spans following incident rheumatoid arthritis (RA). Furthermore, to investigate the impact of IHD on the development of HF and the impact of different treatment era's of RA.

METHODS: This matched cohort study used nationwide, prospectively collected data. From the total Danish population of approximately 5.7 million inhabitants we identified 51,859 patients (between 1995 and July 2016) with incident RA and a sex and age matched cohort from the general population (256,653 persons).

RESULTS: The hazard ratio (HR) for HF among RA patients compared with persons from comparison cohort were 2.28 within the first year of index date, 1.39 within1-5 years of index date, and 1.38 within 5-10 after index date. No difference was identified regarding different treatment era's of RA. For IHD the sHR was 1.93 within the first year of index date, 1.26 within 1-5 years of index date, and 1.31 within 5-10 after index date. Coronary revascularization was also more common within the first year after diagnosis of RA. An increased risk of percutaneous coronary intervention and coronary by-pass grafting within 10 years following the RA diagnosis were observed. HR for new onset of HF in RA without IHD was 1.23, while the HR for new onset of HF in patients with RA and IHD was 2.06.

CONCLUSIONS: RA patients had higher rates of HF and IHD throughout the entire observation period compared to the comparison cohort. RA was associated with a larger risk for developing HF. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalEuropean Journal of Clinical Investigation. Supplement
Volume48
Issue5
ISSN0960-135X
DOIs
Publication statusPublished - 1 May 2018

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