Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Gregor K. Wenning, Innsbruck University
  • ,
  • François Tison, Hopital du Haut-Leveque
  • ,
  • Klaus Seppi, Innsbruck University
  • ,
  • Cristina Sampiao, Centro de Neurosciencas
  • ,
  • Anja Diem, Innsbruck University
  • ,
  • Farid Yekhlef, Hopital du Haut-Leveque
  • ,
  • Imad Ghorayeb, Hopital du Haut-Leveque
  • ,
  • Fabienne Ory, Faculté de Médecine
  • ,
  • Monique Galitzky, Faculté de Médecine
  • ,
  • Tommaso Scaravilli, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London
  • ,
  • Maria Bozi, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London
  • ,
  • Carlo Colosimo, Sapienza University of Rome
  • ,
  • Sid Gilman, University of Michigan, Ann Arbor, Michigan.
  • ,
  • Clifford W. Shults, University of California, San Diego, Medical Center
  • ,
  • Niall P. Quinn, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London
  • ,
  • Olivier Rascol, Faculté de Médecine
  • ,
  • Werner Poewe, Innsbruck University
  • ,
  • Erik Dupont
  • ,
  • Karen Ostergaard
  • ,
  • Eduardo Tolosa
  • ,
  • Thomas Klockgether
  • ,
  • Richard Dodel
  • ,
  • Michael Abele
  • ,
  • Pierre Pollak
  • ,
  • Felix Geser
  • ,
  • Michaela Stamfer
  • ,
  • Günther Deuschl
  • ,
  • Christine Daniels
  • ,
  • Miguel Coelho
  • ,
  • Zvezdan Pirtosek
  • ,
  • David J. Brooks
  • Claire Fowler
  • ,
  • Andrew Lees
  • ,
  • Christopher J. Mathias
  • ,
  • Tamas Revesz
  • ,
  • Alexander Gerhard
  • ,
  • Janice Holton
  • ,
  • Anette Schrag
  • ,
  • Nick Wood
  • ,
  • Olle Lindvall
  • ,
  • Håkan Widner
  • ,
  • Martin Grabowski
  • ,
  • Christer F. Nilsson
  • ,
  • Wolfgang Oertel
  • ,
  • Karla Maria Eggert
  • ,
  • Nicole Schimke
  • ,
  • Alberto Albanese
  • ,
  • Francesco del Sorbo
  • ,
  • Paolo Barone
  • ,
  • Francesco Carella
  • ,
  • Ruth Djaljetti
  • ,
  • Giuseppe Meco
  • ,
  • Jose Berciano
  • ,
  • Andres Gonzalez-Mandly
  • ,
  • Nir Giladi
  • ,
  • Tanya Gurevich
  • ,
  • Thomas Gasser
  • ,
  • Christoph Kamm
  • ,
  • Sten Magnus Aquilonius
  • ,
  • Jonas Bergquist

We aimed to develop and validate a novel rating scale for multiple system atrophy (Unified Multiple System Atrophy Rating Scale - UMSARS). The scale comprises the following components: Part I, historical, 12 items; Part II, motor examination, 14 items; Part III, autonomic examination; and Part IV, global disability scale. For validation purposes, 40 MSA patients were assessed in four centers by 4 raters per center (2 senior and 2 junior raters). The raters applied the UMSARS, as well as a range of other scales, including the Unified Parkinson's Disease Rating Scale (UPDRS) and the International Cooperative Ataxia Rating Scale (ICARS). Internal consistency was high for both UMSARS-1 (Crohnbach's alpha = 0.84) and UMSARS-II (Crohnbach's alpha = 0.90) sections. The interrater reliability of most of the UMSARS-I and -II items as well as of total UMSARS-I and -II subscores was substantial (k (w) = 0.6-0.8) to excellent (k (w) > 0.8). UMSARS-II correlated well with UPDRS-III and ICARS (rs > 0.8). Depending on the degree of the patient's disability, completion of the entire UMSARS took 30 to 45 minutes. Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients.

Original languageEnglish
JournalMovement Disorders
Volume19
Issue12
Pages (from-to)1391-1402
Number of pages12
ISSN0885-3185
DOIs
Publication statusPublished - 1 Dec 2004

    Research areas

  • Internal consistency, Interrater Reliability, Unified Multiple System Atrophy Rating Scale, Validation

See relations at Aarhus University Citationformats

ID: 131251606