Department of Psychology and Behavioural Sciences

Development and preliminary validation of the Adolescent Psoriasis Quality of Life instrument (APso-QOL): a disease-specific measure of quality of life in adolescents with psoriasis

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Development and preliminary validation of the Adolescent Psoriasis Quality of Life instrument (APso-QOL) : a disease-specific measure of quality of life in adolescents with psoriasis. / Randa, H; Khoury, L R; Grønborg, T K; Lomholt, J J; Skov, L; Zachariae, R.

In: British Journal of Dermatology, Vol. 183, No. 1, 07.2020, p. 96-104.

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@article{442fddcf7c61473cb7663048a287cbf5,
title = "Development and preliminary validation of the Adolescent Psoriasis Quality of Life instrument (APso-QOL): a disease-specific measure of quality of life in adolescents with psoriasis",
abstract = "BACKGROUND: No age-appropriate and disease-specific instrument currently exists to measure health-related quality of life (HRQOL) in adolescents with psoriasis (12-17 years).OBJECTIVES: To develop and provide preliminary validation of the Adolescent Psoriasis Quality of Life instrument (APso-QOL).METHODS: Qualitative interviews with adolescents with psoriasis, parents of adolescents with psoriasis, and health care professionals informed the development of an initial item pool for the APso-QOL, which was subsequently refined through cognitive interviews. Finally, data from an independent sample of adolescents with psoriasis was used for item reduction, scale construction, and initial validation, using a combination of techniques from classical test theory and Rasch modelling.RESULTS: Rich qualitative data concerning HRQOL in adolescents with psoriasis (18 adolescents, 14 parents, and 4 health care professionals) combined with cognitive interview testing (n = 12) resulted in a 41-item draft version. Item reduction led to the final APso-QOL; a 17-item instrument consisting of two subscales showing good fit to their respective Rasch models: Psychosocial Impact (APso-PI; 12 items) and impact of Physical Symptoms and Treatment (APso-PST; 5 items) (n=50). All a priori stated hypotheses regarding construct validity were supported. Both subscales and the total scale showed acceptable test-retest reliabilities (intra-class correlations 0.97, 0.89, and 0.96) and internal consistencies (Cronbach's α 0.94, 0.81, and 0.95).CONCLUSIONS: The preliminary form of the instrument APso-QOL shows promising psychometric properties. It can be used in daily clinical practice and research to support a patient-centered approach and inform treatment planning.",
keywords = "CHILDREN, INDEX, OUTCOMES PRO INSTRUMENTS, RELIABILITY, RESPONSIVENESS, VALIDITY",
author = "H Randa and Khoury, {L R} and Gr{\o}nborg, {T K} and Lomholt, {J J} and L Skov and R Zachariae",
note = "{\textcopyright} 2019 British Association of Dermatologists.",
year = "2020",
month = jul,
doi = "10.1111/bjd.18719",
language = "English",
volume = "183",
pages = "96--104",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Development and preliminary validation of the Adolescent Psoriasis Quality of Life instrument (APso-QOL)

T2 - a disease-specific measure of quality of life in adolescents with psoriasis

AU - Randa, H

AU - Khoury, L R

AU - Grønborg, T K

AU - Lomholt, J J

AU - Skov, L

AU - Zachariae, R

N1 - © 2019 British Association of Dermatologists.

PY - 2020/7

Y1 - 2020/7

N2 - BACKGROUND: No age-appropriate and disease-specific instrument currently exists to measure health-related quality of life (HRQOL) in adolescents with psoriasis (12-17 years).OBJECTIVES: To develop and provide preliminary validation of the Adolescent Psoriasis Quality of Life instrument (APso-QOL).METHODS: Qualitative interviews with adolescents with psoriasis, parents of adolescents with psoriasis, and health care professionals informed the development of an initial item pool for the APso-QOL, which was subsequently refined through cognitive interviews. Finally, data from an independent sample of adolescents with psoriasis was used for item reduction, scale construction, and initial validation, using a combination of techniques from classical test theory and Rasch modelling.RESULTS: Rich qualitative data concerning HRQOL in adolescents with psoriasis (18 adolescents, 14 parents, and 4 health care professionals) combined with cognitive interview testing (n = 12) resulted in a 41-item draft version. Item reduction led to the final APso-QOL; a 17-item instrument consisting of two subscales showing good fit to their respective Rasch models: Psychosocial Impact (APso-PI; 12 items) and impact of Physical Symptoms and Treatment (APso-PST; 5 items) (n=50). All a priori stated hypotheses regarding construct validity were supported. Both subscales and the total scale showed acceptable test-retest reliabilities (intra-class correlations 0.97, 0.89, and 0.96) and internal consistencies (Cronbach's α 0.94, 0.81, and 0.95).CONCLUSIONS: The preliminary form of the instrument APso-QOL shows promising psychometric properties. It can be used in daily clinical practice and research to support a patient-centered approach and inform treatment planning.

AB - BACKGROUND: No age-appropriate and disease-specific instrument currently exists to measure health-related quality of life (HRQOL) in adolescents with psoriasis (12-17 years).OBJECTIVES: To develop and provide preliminary validation of the Adolescent Psoriasis Quality of Life instrument (APso-QOL).METHODS: Qualitative interviews with adolescents with psoriasis, parents of adolescents with psoriasis, and health care professionals informed the development of an initial item pool for the APso-QOL, which was subsequently refined through cognitive interviews. Finally, data from an independent sample of adolescents with psoriasis was used for item reduction, scale construction, and initial validation, using a combination of techniques from classical test theory and Rasch modelling.RESULTS: Rich qualitative data concerning HRQOL in adolescents with psoriasis (18 adolescents, 14 parents, and 4 health care professionals) combined with cognitive interview testing (n = 12) resulted in a 41-item draft version. Item reduction led to the final APso-QOL; a 17-item instrument consisting of two subscales showing good fit to their respective Rasch models: Psychosocial Impact (APso-PI; 12 items) and impact of Physical Symptoms and Treatment (APso-PST; 5 items) (n=50). All a priori stated hypotheses regarding construct validity were supported. Both subscales and the total scale showed acceptable test-retest reliabilities (intra-class correlations 0.97, 0.89, and 0.96) and internal consistencies (Cronbach's α 0.94, 0.81, and 0.95).CONCLUSIONS: The preliminary form of the instrument APso-QOL shows promising psychometric properties. It can be used in daily clinical practice and research to support a patient-centered approach and inform treatment planning.

KW - CHILDREN

KW - INDEX

KW - OUTCOMES PRO INSTRUMENTS

KW - RELIABILITY

KW - RESPONSIVENESS

KW - VALIDITY

UR - http://www.scopus.com/inward/record.url?scp=85078942299&partnerID=8YFLogxK

U2 - 10.1111/bjd.18719

DO - 10.1111/bjd.18719

M3 - Journal article

C2 - 31743420

VL - 183

SP - 96

EP - 104

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 1

ER -