Department of Psychology and Behavioural Sciences

Development and preliminary validation of the Adolescent Psoriasis Quality of Life instrument (APso-QOL): a disease-specific measure of quality of life in adolescents with psoriasis

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BACKGROUND: No age-appropriate and disease-specific instrument currently exists to measure health-related quality of life (HRQOL) in adolescents with psoriasis (12-17 years).

OBJECTIVES: To develop and provide preliminary validation of the Adolescent Psoriasis Quality of Life instrument (APso-QOL).

METHODS: Qualitative interviews with adolescents with psoriasis, parents of adolescents with psoriasis, and health care professionals informed the development of an initial item pool for the APso-QOL, which was subsequently refined through cognitive interviews. Finally, data from an independent sample of adolescents with psoriasis was used for item reduction, scale construction, and initial validation, using a combination of techniques from classical test theory and Rasch modelling.

RESULTS: Rich qualitative data concerning HRQOL in adolescents with psoriasis (18 adolescents, 14 parents, and 4 health care professionals) combined with cognitive interview testing (n = 12) resulted in a 41-item draft version. Item reduction led to the final APso-QOL; a 17-item instrument consisting of two subscales showing good fit to their respective Rasch models: Psychosocial Impact (APso-PI; 12 items) and impact of Physical Symptoms and Treatment (APso-PST; 5 items) (n=50). All a priori stated hypotheses regarding construct validity were supported. Both subscales and the total scale showed acceptable test-retest reliabilities (intra-class correlations 0.97, 0.89, and 0.96) and internal consistencies (Cronbach's α 0.94, 0.81, and 0.95).

CONCLUSIONS: The preliminary form of the instrument APso-QOL shows promising psychometric properties. It can be used in daily clinical practice and research to support a patient-centered approach and inform treatment planning.

Original languageEnglish
JournalBritish Journal of Dermatology
ISSN0007-0963
DOIs
Publication statusE-pub ahead of print - 19 Nov 2019

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