Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10

Eva Sonnenberg-Riethmacher; Michaela Miehe; Claus C. Stolt; Derk E. Goerich; Michael Wegner; Dieter Riethmacher

Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10

Eva Sonnenberg-Riethmacher, Michaela Miehe, Claus C. Stolt, Derk E. Goerich, Michael Wegner, Dieter Riethmacher

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Abstract
The HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.

Original language	English
Journal	Mechanisms of Development
Volume	109
Issue	2
Pages (from-to)	253
Number of pages	265
ISSN	0925-4773
Publication status	Published - Dec 2001

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@article{7833554ecce44cab9e2ea5b1bdb92be2,

title = "Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10",

abstract = "AbstractThe HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.",

author = "Eva Sonnenberg-Riethmacher and Michaela Miehe and Stolt, {Claus C.} and Goerich, {Derk E.} and Michael Wegner and Dieter Riethmacher",

year = "2001",

month = dec,

language = "English",

volume = "109",

pages = "253",

journal = "Mechanisms of Development",

issn = "0925-4773",

publisher = "Elsevier Ireland Ltd.",

number = "2",

}

Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10. / Sonnenberg-Riethmacher, Eva; Miehe, Michaela; Stolt, Claus C. et al.
In: Mechanisms of Development, Vol. 109, No. 2, 12.2001, p. 253.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10

AU - Sonnenberg-Riethmacher, Eva

AU - Miehe, Michaela

AU - Stolt, Claus C.

AU - Goerich, Derk E.

AU - Wegner, Michael

AU - Riethmacher, Dieter

PY - 2001/12

Y1 - 2001/12

N2 - AbstractThe HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.

AB - AbstractThe HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.

M3 - Journal article

SN - 0925-4773

VL - 109

SP - 253

JO - Mechanisms of Development

JF - Mechanisms of Development

IS - 2

ER -

Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10

Abstract

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