Determinants of Maternal Insulin Resistance during Pregnancy: An Updated Overview

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Determinants of Maternal Insulin Resistance during Pregnancy : An Updated Overview. / Kampmann, Ulla; Knorr, Sine; Fuglsang, Jens; Ovesen, Per.

In: Journal of Diabetes Research, Vol. 2019, 5320156, 11.2019.

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@article{e0b7ca20d2b64b4b9978412b7945cdf2,
title = "Determinants of Maternal Insulin Resistance during Pregnancy: An Updated Overview",
abstract = "Insulin resistance changes over time during pregnancy, and in the last half of the pregnancy, insulin resistance increases considerably and can become severe, especially in women with gestational diabetes and type 2 diabetes. Numerous factors such as placental hormones, obesity, inactivity, an unhealthy diet, and genetic and epigenetic contributions influence insulin resistance in pregnancy, but the causal mechanisms are complex and still not completely elucidated. In this review, we strive to give an overview of the many components that have been ascribed to contribute to the insulin resistance in pregnancy. Knowledge about the causes and consequences of insulin resistance is of extreme importance in order to establish the best possible treatment during pregnancy as severe insulin resistance can result in metabolic dysfunction in both mother and offspring on a short as well as long-term basis.",
keywords = "GENE-EXPRESSION, GESTATIONAL DIABETES-MELLITUS, GLUCOSE-TOLERANCE, PHYSICAL-ACTIVITY, PLACENTAL GROWTH-HORMONE, PRENATAL EXPOSURE, SENSITIVITY, SKELETAL-MUSCLE, TNF-ALPHA, WOMEN",
author = "Ulla Kampmann and Sine Knorr and Jens Fuglsang and Per Ovesen",
note = "Copyright {\circledC} 2019 Ulla Kampmann et al.",
year = "2019",
month = "11",
doi = "10.1155/2019/5320156",
language = "English",
volume = "2019",
journal = "Journal of Diabetes Research",
issn = "2314-6745",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Determinants of Maternal Insulin Resistance during Pregnancy

T2 - An Updated Overview

AU - Kampmann, Ulla

AU - Knorr, Sine

AU - Fuglsang, Jens

AU - Ovesen, Per

N1 - Copyright © 2019 Ulla Kampmann et al.

PY - 2019/11

Y1 - 2019/11

N2 - Insulin resistance changes over time during pregnancy, and in the last half of the pregnancy, insulin resistance increases considerably and can become severe, especially in women with gestational diabetes and type 2 diabetes. Numerous factors such as placental hormones, obesity, inactivity, an unhealthy diet, and genetic and epigenetic contributions influence insulin resistance in pregnancy, but the causal mechanisms are complex and still not completely elucidated. In this review, we strive to give an overview of the many components that have been ascribed to contribute to the insulin resistance in pregnancy. Knowledge about the causes and consequences of insulin resistance is of extreme importance in order to establish the best possible treatment during pregnancy as severe insulin resistance can result in metabolic dysfunction in both mother and offspring on a short as well as long-term basis.

AB - Insulin resistance changes over time during pregnancy, and in the last half of the pregnancy, insulin resistance increases considerably and can become severe, especially in women with gestational diabetes and type 2 diabetes. Numerous factors such as placental hormones, obesity, inactivity, an unhealthy diet, and genetic and epigenetic contributions influence insulin resistance in pregnancy, but the causal mechanisms are complex and still not completely elucidated. In this review, we strive to give an overview of the many components that have been ascribed to contribute to the insulin resistance in pregnancy. Knowledge about the causes and consequences of insulin resistance is of extreme importance in order to establish the best possible treatment during pregnancy as severe insulin resistance can result in metabolic dysfunction in both mother and offspring on a short as well as long-term basis.

KW - GENE-EXPRESSION

KW - GESTATIONAL DIABETES-MELLITUS

KW - GLUCOSE-TOLERANCE

KW - PHYSICAL-ACTIVITY

KW - PLACENTAL GROWTH-HORMONE

KW - PRENATAL EXPOSURE

KW - SENSITIVITY

KW - SKELETAL-MUSCLE

KW - TNF-ALPHA

KW - WOMEN

U2 - 10.1155/2019/5320156

DO - 10.1155/2019/5320156

M3 - Review

C2 - 31828161

VL - 2019

JO - Journal of Diabetes Research

JF - Journal of Diabetes Research

SN - 2314-6745

M1 - 5320156

ER -