Determinants of Maternal Insulin Resistance during Pregnancy: An Updated Overview

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Insulin resistance changes over time during pregnancy, and in the last half of the pregnancy, insulin resistance increases considerably and can become severe, especially in women with gestational diabetes and type 2 diabetes. Numerous factors such as placental hormones, obesity, inactivity, an unhealthy diet, and genetic and epigenetic contributions influence insulin resistance in pregnancy, but the causal mechanisms are complex and still not completely elucidated. In this review, we strive to give an overview of the many components that have been ascribed to contribute to the insulin resistance in pregnancy. Knowledge about the causes and consequences of insulin resistance is of extreme importance in order to establish the best possible treatment during pregnancy as severe insulin resistance can result in metabolic dysfunction in both mother and offspring on a short as well as long-term basis.

Original languageEnglish
Article number5320156
JournalJournal of Diabetes Research
Volume2019
Number of pages9
ISSN2314-6745
DOIs
Publication statusPublished - Nov 2019

    Research areas

  • GENE-EXPRESSION, GESTATIONAL DIABETES-MELLITUS, GLUCOSE-TOLERANCE, PHYSICAL-ACTIVITY, PLACENTAL GROWTH-HORMONE, PRENATAL EXPOSURE, SENSITIVITY, SKELETAL-MUSCLE, TNF-ALPHA, WOMEN

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