Detection of sexually antagonistic transmission distortions in trio datasets

Elise A. Lucotte*, Clara Albiñana, Romain Laurent, Claude Bhérer, Thomas Bataillon, Bruno Toupance, Genome of the Netherland Consortium

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperLetterpeer-review

Abstract

Sexual dimorphisms are widespread in animals and plants, for morphological as well as physiological traits. Understanding the genetic basis of sexual dimorphism and its evolution is crucial for understanding biological differences between the sexes. Genetic variants with sex-antagonistic effects on fitness are expected to segregate in populations at the early phases of sexual dimorphism emergence. Detecting such variants is notoriously difficult, and the few genome-scan methods employed so far have limited power and little specificity. Here, we propose a new framework to detect a signature of sexually antagonistic (SA) selection. We rely on trio datasets where sex-biased transmission distortions can be directly tracked from parents to offspring, and identify signals of SA transmission distortions in genomic regions. We report the genomic location of six candidate regions detected in human populations as potentially under sexually antagonist selection. We find an enrichment of genes associated with embryonic development within these regions. Last, we highlight two candidate regions for SA selection in humans.

Original languageEnglish
JournalEvolution Letters
Volume6
Issue2
Pages (from-to)203-216
Number of pages14
ISSN2056-3744
DOIs
Publication statusPublished - Apr 2022

Keywords

  • CONFLICT
  • EVOLUTION
  • FITNESS
  • GENOTYPES
  • Human population genetics
  • LINKAGE DISEQUILIBRIUM
  • SELECTION
  • SEXES
  • SIGNATURES
  • intralocus sexual conflict
  • sexual dimorphisms
  • sexually antagonistic selection
  • transmission distortion

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