TY - JOUR
T1 - Detection of interictal epileptiform discharges
T2 - A comparison of on-scalp MEG and conventional MEG measurements
AU - Westin, Karin
AU - Pfeiffer, Christoph
AU - Andersen, Lau M.
AU - Ruffieux, Silvia
AU - Cooray, Gerald
AU - Kalaboukhov, Alexei
AU - Winkler, Dag
AU - Ingvar, Martin
AU - Schneiderman, Justin
AU - Lundqvist, Daniel
PY - 2020/8
Y1 - 2020/8
N2 - Objective: Conventional MEG provides an unsurpassed ability to, non-invasively, detect epileptic activity. However, highly resolved information on small neuronal populations required in epilepsy diagnostics is lost and can be detected only intracranially. Next-generation on-scalp magnetencephalography (MEG) sensors aim to retrieve information unavailable to conventional non-invasive brain imaging techniques. To evaluate the benefits of on-scalp MEG in epilepsy, we performed the first-ever such measurement on an epilepsy patient. Methods: Conducted as a benchmarking study focusing on interictal epileptiform discharge (IED) detectability, an on-scalp high-temperature superconducting quantum interference device magnetometer (high-Tc SQUID) system was compared to a conventional, low-temperature SQUID system. Co-registration of electroencephalopraphy (EEG) was performed. A novel machine learning-based IED-detection algorithm was developed to aid identification of on-scalp MEG unique IEDs. Results: Conventional MEG contained 24 IEDs. On-scalp MEG revealed 47 IEDs (16 co-registered by EEG, 31 unique to the on-scalp MEG recording). Conclusion: Our results indicate that on-scalp MEG might capture IEDs not seen by other non-invasive modalities. Significance: On-scalp MEG has the potential of improving non-invasive epilepsy evaluation.
AB - Objective: Conventional MEG provides an unsurpassed ability to, non-invasively, detect epileptic activity. However, highly resolved information on small neuronal populations required in epilepsy diagnostics is lost and can be detected only intracranially. Next-generation on-scalp magnetencephalography (MEG) sensors aim to retrieve information unavailable to conventional non-invasive brain imaging techniques. To evaluate the benefits of on-scalp MEG in epilepsy, we performed the first-ever such measurement on an epilepsy patient. Methods: Conducted as a benchmarking study focusing on interictal epileptiform discharge (IED) detectability, an on-scalp high-temperature superconducting quantum interference device magnetometer (high-Tc SQUID) system was compared to a conventional, low-temperature SQUID system. Co-registration of electroencephalopraphy (EEG) was performed. A novel machine learning-based IED-detection algorithm was developed to aid identification of on-scalp MEG unique IEDs. Results: Conventional MEG contained 24 IEDs. On-scalp MEG revealed 47 IEDs (16 co-registered by EEG, 31 unique to the on-scalp MEG recording). Conclusion: Our results indicate that on-scalp MEG might capture IEDs not seen by other non-invasive modalities. Significance: On-scalp MEG has the potential of improving non-invasive epilepsy evaluation.
KW - Epilepsy
KW - High-critical temperature SQUIDs
KW - Instrumentation
KW - Interictal epileptiform discharges
KW - Magnetoencephalography
UR - http://www.scopus.com/inward/record.url?scp=85085749045&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2020.03.041
DO - 10.1016/j.clinph.2020.03.041
M3 - Journal article
C2 - 32504930
AN - SCOPUS:85085749045
SN - 1388-2457
VL - 131
SP - 1711
EP - 1720
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
IS - 8
ER -