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Detection of information flow between cortical laminae activities and auditory evoked potentials in rats by means of Granger causality

Research output: Contribution to book/anthology/report/proceedingArticle in proceedingsResearchpeer-review

  • Zeinab Schaefer
  • L. Haab, Saarland University
  • ,
  • K. Schwerdtfeger, Saarland University
  • ,
  • K. Takahashi, University of Chicago
  • ,
  • D. J. Strauss, Saarland University

We seek to understand the relation between invasive high-resolution data and non-invasive measurement in an animal model in an auditory sensory adaptation experimental setting. In a previous study, we estimated the mutual information between the phase of auditory evoked responses (AER) with the phase of local field potentials (LFP) of auditory cortices at different frequency ranges. The results showed a consistently high level of information sharing between the AER activities as well as the responses from the granular layer, which was known as the main thalamo-recipient layer. However, mutual information was fundamentally an undirected measure of information flow. In this study we investigated how well we could characterize direction of information flow, by using Granger causality (GC), between different cortical laminae and functional projections on to the AER activities. We obtained that based on the GC coefficients, we are able to extract the connectivity between different cortical laminae to some extend and also a strong connection between the AER and granular layer. In our future study, we would like to construct a reliable picture of network connectivity, both functionally and anatomically, between different layers at more specified frequencies and much finer temporal resolutions.

Original languageEnglish
Title of host publication42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC)
Number of pages4
Place of publication Montreal, QC
PublisherIEEE
Publication yearJul 2020
Pages876-879
ISBN (Electronic)9781728119908
DOIs
Publication statusPublished - Jul 2020
Event42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020 - Montreal, Canada
Duration: 20 Jul 202024 Jul 2020

Conference

Conference42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020
LandCanada
ByMontreal
Periode20/07/202024/07/2020
SeriesProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume2020-July
ISSN1557-170X

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