Detection and quantification of proviral HIV-1 184 M/V in circulating CD4(+) T cells of patients on HAART with a viremia less than 1000 copies/ml

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Rajesh Mohey, Denmark
  • Anne Louise Jørgensen, Aalborg Universitetsbibliotek, Denmark
  • Bjarne K Møller
  • Finn T Black, Denmark
  • Jørgen Kjems
  • Niels Obel, Institut for Ortopædi og Intern Medicin, Denmark
Highly active anti-retroviral therapy (HAART) effectively reduces HIV replication but does not completely hinder it. Sub-optimal therapy leads to HIV resistance to the drugs administered. However, the role of low-level viremia (viral-load less than 1,000 copies/ml) on mutation genesis and incorporation of resistant forms in the long-lived CD4(+) T cellular DNA compartment is not clear.
Original languageEnglish
JournalJournal of Clinical Virology
Volume34
Issue4
Pages (from-to)257-267
Number of pages11
ISSN1386-6532
DOIs
Publication statusPublished - 2005

    Research areas

  • Adult, Aged, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, CD4-Positive T-Lymphocytes, Cross-Sectional Studies, DNA, Viral, Drug Resistance, Viral, Female, HIV Infections, HIV-1, Humans, Lamivudine, Male, Middle Aged, Mutation, Proviruses, Viremia

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