Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Standard

Design principles of ocular drug delivery systems : importance of drug payload, release rate, and material properties. / Subrizi, Astrid; del Amo, Eva M.; Korzhikov-Vlakh, Viktor; Tennikova, Tatiana; Ruponen, Marika; Urtti, Arto.

In: Drug Discovery Today, Vol. 24, No. 8, 08.2019, p. 1446-1457.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Harvard

Subrizi, A, del Amo, EM, Korzhikov-Vlakh, V, Tennikova, T, Ruponen, M & Urtti, A 2019, 'Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties', Drug Discovery Today, vol. 24, no. 8, pp. 1446-1457. https://doi.org/10.1016/j.drudis.2019.02.001

APA

Subrizi, A., del Amo, E. M., Korzhikov-Vlakh, V., Tennikova, T., Ruponen, M., & Urtti, A. (2019). Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties. Drug Discovery Today, 24(8), 1446-1457. https://doi.org/10.1016/j.drudis.2019.02.001

CBE

Subrizi A, del Amo EM, Korzhikov-Vlakh V, Tennikova T, Ruponen M, Urtti A. 2019. Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties. Drug Discovery Today. 24(8):1446-1457. https://doi.org/10.1016/j.drudis.2019.02.001

MLA

Vancouver

Subrizi A, del Amo EM, Korzhikov-Vlakh V, Tennikova T, Ruponen M, Urtti A. Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties. Drug Discovery Today. 2019 Aug;24(8):1446-1457. https://doi.org/10.1016/j.drudis.2019.02.001

Author

Subrizi, Astrid ; del Amo, Eva M. ; Korzhikov-Vlakh, Viktor ; Tennikova, Tatiana ; Ruponen, Marika ; Urtti, Arto. / Design principles of ocular drug delivery systems : importance of drug payload, release rate, and material properties. In: Drug Discovery Today. 2019 ; Vol. 24, No. 8. pp. 1446-1457.

Bibtex

@article{2c705352fc054f5d9c1d73960df8647e,
title = "Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties",
abstract = "Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling.",
author = "Astrid Subrizi and {del Amo}, {Eva M.} and Viktor Korzhikov-Vlakh and Tatiana Tennikova and Marika Ruponen and Arto Urtti",
year = "2019",
month = "8",
doi = "10.1016/j.drudis.2019.02.001",
language = "English",
volume = "24",
pages = "1446--1457",
journal = "Drug Discovery Today",
issn = "1359-6446",
publisher = "Elsevier Ltd. * Trends Journals",
number = "8",

}

RIS

TY - JOUR

T1 - Design principles of ocular drug delivery systems

T2 - importance of drug payload, release rate, and material properties

AU - Subrizi, Astrid

AU - del Amo, Eva M.

AU - Korzhikov-Vlakh, Viktor

AU - Tennikova, Tatiana

AU - Ruponen, Marika

AU - Urtti, Arto

PY - 2019/8

Y1 - 2019/8

N2 - Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling.

AB - Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling.

UR - http://www.scopus.com/inward/record.url?scp=85061607596&partnerID=8YFLogxK

U2 - 10.1016/j.drudis.2019.02.001

DO - 10.1016/j.drudis.2019.02.001

M3 - Review

VL - 24

SP - 1446

EP - 1457

JO - Drug Discovery Today

JF - Drug Discovery Today

SN - 1359-6446

IS - 8

ER -