Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties

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  • Astrid Subrizi, University of Eastern Finland
  • ,
  • Eva M. del Amo, Manchester University
  • ,
  • Viktor Korzhikov-Vlakh, Saint Petersburg State University
  • ,
  • Tatiana Tennikova, Saint Petersburg State University
  • ,
  • Marika Ruponen, University of Eastern Finland
  • ,
  • Arto Urtti, University of Eastern Finland, Saint Petersburg State University, University of Helsinki

Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling.

Original languageEnglish
JournalDrug Discovery Today
Pages (from-to)1446-1457
Number of pages12
Publication statusPublished - Aug 2019

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