Design and construction of double-decker tile as a route to three-dimensional periodic assembly of DNA

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Urmi Majumder
  • ,
  • Abhijit Rangnekar, Denmark
  • Kurt V Gothelf
  • John H Reif
  • ,
  • Thomas H LaBean
  • iNano-School
  • Interdisciplinary Nanoscience Center
  • Department of Chemistry
DNA is a useful material for nanoscale construction. Due to highly specific Watson-Crick base pairing, the DNA sequences can be designed to form small tiles or origami. Adjacent helices in such nanostructures are connected via Holliday junction-like crossovers. DNA tiles can have sticky ends which can then be programmed to form large one-dimensional and two-dimensional periodic lattices. Recently, a three-dimensional DNA lattice has also been constructed. Here we report the design and construction of a novel DNA cross tile, called the double-decker tile. Its arms are symmetric and have four double helices each. Using its sticky ends, large two-dimensional square lattices have been constructed which are on the order of tens of micrometers. Furthermore, it is proposed that the sticky ends of the double-decker tile can be programmed to form a three-dimensional periodic lattice with large cavities that could be used as a scaffold for precise positioning of molecules in space.
Original languageEnglish
JournalJournal of the American Chemical Society
Volume133
Issue11
Pages (from-to)3843-5
Number of pages3
ISSN0002-7863
DOIs
Publication statusPublished - 23 Mar 2011

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