Depression in Parkinson's disease: Loss of dopamine and noradrenaline innervation in the limbic system

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  • Philippe Remy, CHU Henri Mondor et Faculté de Médecine Paris 12, Hammersmith Hospital
  • ,
  • Miroslava Doder, Hammersmith Hospital
  • ,
  • Andrew Lees, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London
  • ,
  • Nora Turjanski, Hammersmith Hospital
  • ,
  • David Brooks

The reason for the high frequency of depression and anxiety in Parkinson's disease is poorly understood. Degeneration of neurotransmitter systems other than dopamine might play a specific role in the occurrence of these affective disorders. We used [11C]RTI-32 PET, an in vivo marker of both dopamine and noradrenaline transporter binding, to localize differences between depressed and non-depressed patients. We studied eight and 12 Parkinson's disease patients with and without a history of depression matched for age, disease duration and doses of antiparkinsonian medication. The depressed Parkinson's disease cohort had lower [11C]RTI-32 binding than non-depressed Parkinson's disease cases in the locus coeruleus and in several regions of the limbic system including the anterior cingulate cortex, the thalamus, the amygdala and the ventral striatum. Exploratory analyses revealed that the severity of anxiety in the Parkinson's disease patients was inversely correlated with the [11C]RTI-32 binding in most of these regions and apathy was inversely correlated with [11C]RTI-32 binding in the ventral striatum. These results suggest that depression and anxiety in Parkinson's disease might be associated with a specific loss of dopamine and noradrenaline innervation in the limbic system.

Original languageEnglish
Pages (from-to)1314-1322
Number of pages9
Publication statusPublished - 1 Jan 2005
Externally publishedYes

    Research areas

  • Catecholamines, Depression, Limbic system, Parkinson's disease, PET imaging

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