Depauperate genetic variability detected in the American and European bison using genomic techniques

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Depauperate genetic variability detected in the American and European bison using genomic techniques. / Pertoldi, Cino; Tokarska, Magorzata; Wójcik, Jan M; Andersen, Ditte Holm; Loeschcke, Volker; Gregersen, Vivi; Coltman, David; Wilson, Gregory A; Randi, Ettore; Hansen, Michael M; Bendixen, Christian.

In: Biology Direct, Vol. 4, No. 48, 2009, p. 48; discussion 48.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Pertoldi, C, Tokarska, M, Wójcik, JM, Andersen, DH, Loeschcke, V, Gregersen, V, Coltman, D, Wilson, GA, Randi, E, Hansen, MM & Bendixen, C 2009, 'Depauperate genetic variability detected in the American and European bison using genomic techniques', Biology Direct, vol. 4, no. 48, pp. 48; discussion 48. https://doi.org/10.1186/1745-6150-4-48

APA

CBE

Pertoldi C, Tokarska M, Wójcik JM, Andersen DH, Loeschcke V, Gregersen V, Coltman D, Wilson GA, Randi E, Hansen MM, Bendixen C. 2009. Depauperate genetic variability detected in the American and European bison using genomic techniques. Biology Direct. 4(48):48; discussion 48. https://doi.org/10.1186/1745-6150-4-48

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Author

Pertoldi, Cino ; Tokarska, Magorzata ; Wójcik, Jan M ; Andersen, Ditte Holm ; Loeschcke, Volker ; Gregersen, Vivi ; Coltman, David ; Wilson, Gregory A ; Randi, Ettore ; Hansen, Michael M ; Bendixen, Christian. / Depauperate genetic variability detected in the American and European bison using genomic techniques. In: Biology Direct. 2009 ; Vol. 4, No. 48. pp. 48; discussion 48.

Bibtex

@article{a7883860e2c511dd8b7a000ea68e967b,
title = "Depauperate genetic variability detected in the American and European bison using genomic techniques",
abstract = "A total of 929 polymorphic SNPs in EB (out of 54, 000 SNPs screened using a BovineSNP50 Illumina Genotyping BeadChip), and 1, 524 and 1, 403 polymorphic SNPs in WB and PB, respectively, were analysed. EB, WB and PB have all undergone recent drastic reductions in population size. Accordingly, they exhibited extremely depauperate genomes, deviations from genetic equilibrium and a genome organization consisting of a mosaic of haplotype blocks: regions with low haplotype diversity and high levels of linkage disequilibrium. No evidence for positive or stabilizing selection was found in EB, WB and PB, likely reflecting drift overwhelming selection. We suggest that utilization of genome-wide screening technologies, followed by utilization of less expensive techniques (e.g. VeraCode and Fluidigm EP1), holds large potential for genetic monitoring of populations. Additionally, these techniques will allow radical improvements of breeding practices in captive or managed populations, otherwise hampered by the limited availability of polymorphic markers. This result in improved possibilities for 1) estimating genetic relationships among individuals and 2) designing breeding strategies which attempt to preserve or reduce polymorphism in ecologically relevant genes and/or entire blocks.",
author = "Cino Pertoldi and Magorzata Tokarska and W{\'o}jcik, {Jan M} and Andersen, {Ditte Holm} and Volker Loeschcke and Vivi Gregersen and David Coltman and Wilson, {Gregory A} and Ettore Randi and Hansen, {Michael M} and Christian Bendixen",
year = "2009",
doi = "10.1186/1745-6150-4-48",
language = "English",
volume = "4",
pages = "48; discussion 48",
journal = "Biology Direct",
issn = "1745-6150",
publisher = "BioMed Central Ltd.",
number = "48",

}

RIS

TY - JOUR

T1 - Depauperate genetic variability detected in the American and European bison using genomic techniques

AU - Pertoldi, Cino

AU - Tokarska, Magorzata

AU - Wójcik, Jan M

AU - Andersen, Ditte Holm

AU - Loeschcke, Volker

AU - Gregersen, Vivi

AU - Coltman, David

AU - Wilson, Gregory A

AU - Randi, Ettore

AU - Hansen, Michael M

AU - Bendixen, Christian

PY - 2009

Y1 - 2009

N2 - A total of 929 polymorphic SNPs in EB (out of 54, 000 SNPs screened using a BovineSNP50 Illumina Genotyping BeadChip), and 1, 524 and 1, 403 polymorphic SNPs in WB and PB, respectively, were analysed. EB, WB and PB have all undergone recent drastic reductions in population size. Accordingly, they exhibited extremely depauperate genomes, deviations from genetic equilibrium and a genome organization consisting of a mosaic of haplotype blocks: regions with low haplotype diversity and high levels of linkage disequilibrium. No evidence for positive or stabilizing selection was found in EB, WB and PB, likely reflecting drift overwhelming selection. We suggest that utilization of genome-wide screening technologies, followed by utilization of less expensive techniques (e.g. VeraCode and Fluidigm EP1), holds large potential for genetic monitoring of populations. Additionally, these techniques will allow radical improvements of breeding practices in captive or managed populations, otherwise hampered by the limited availability of polymorphic markers. This result in improved possibilities for 1) estimating genetic relationships among individuals and 2) designing breeding strategies which attempt to preserve or reduce polymorphism in ecologically relevant genes and/or entire blocks.

AB - A total of 929 polymorphic SNPs in EB (out of 54, 000 SNPs screened using a BovineSNP50 Illumina Genotyping BeadChip), and 1, 524 and 1, 403 polymorphic SNPs in WB and PB, respectively, were analysed. EB, WB and PB have all undergone recent drastic reductions in population size. Accordingly, they exhibited extremely depauperate genomes, deviations from genetic equilibrium and a genome organization consisting of a mosaic of haplotype blocks: regions with low haplotype diversity and high levels of linkage disequilibrium. No evidence for positive or stabilizing selection was found in EB, WB and PB, likely reflecting drift overwhelming selection. We suggest that utilization of genome-wide screening technologies, followed by utilization of less expensive techniques (e.g. VeraCode and Fluidigm EP1), holds large potential for genetic monitoring of populations. Additionally, these techniques will allow radical improvements of breeding practices in captive or managed populations, otherwise hampered by the limited availability of polymorphic markers. This result in improved possibilities for 1) estimating genetic relationships among individuals and 2) designing breeding strategies which attempt to preserve or reduce polymorphism in ecologically relevant genes and/or entire blocks.

U2 - 10.1186/1745-6150-4-48

DO - 10.1186/1745-6150-4-48

M3 - Journal article

C2 - 19995416

VL - 4

SP - 48; discussion 48

JO - Biology Direct

JF - Biology Direct

SN - 1745-6150

IS - 48

ER -