TY - JOUR
T1 - Dengue Virus Immunopathogenesis
T2 - Lessons Applicable to the Emergence of Zika Virus
AU - Olagnier, David
AU - Amatore, Donatella
AU - Castiello, Luciano
AU - Ferrari, Matteo
AU - Palermo, Enrico
AU - Diamond, Michael S
AU - Palamara, Anna Teresa
AU - Hiscott, John
N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.
PY - 2016/8/28
Y1 - 2016/8/28
N2 - Dengue is the leading mosquito-transmitted viral infection in the world. There are more than 390 million new infections annually; while the majority of infected individuals are asymptomatic or develop a self-limited dengue fever, up to 1 million clinical cases develop severe manifestations, including dengue hemorrhagic fever and shock syndrome, resulting in ~25,000 deaths annually, mainly in children. Gaps in our understanding of the mechanisms that contribute to dengue infection and immunopathogenesis have hampered the development of vaccines and antiviral agents. Some of these limitations are highlighted by the explosive re-emergence of another arthropod-borne flavivirus-Zika virus-spread by the same vector, the Aedes aegypti mosquito, that also carries dengue, yellow fever and chikungunya viruses. This review will discuss the early virus-host interactions in dengue infection, with emphasis on the interrelationship between oxidative stress and innate immune pathways, and will provide insight as to how lessons learned from dengue research may expedite therapeutic strategies for Zika virus.
AB - Dengue is the leading mosquito-transmitted viral infection in the world. There are more than 390 million new infections annually; while the majority of infected individuals are asymptomatic or develop a self-limited dengue fever, up to 1 million clinical cases develop severe manifestations, including dengue hemorrhagic fever and shock syndrome, resulting in ~25,000 deaths annually, mainly in children. Gaps in our understanding of the mechanisms that contribute to dengue infection and immunopathogenesis have hampered the development of vaccines and antiviral agents. Some of these limitations are highlighted by the explosive re-emergence of another arthropod-borne flavivirus-Zika virus-spread by the same vector, the Aedes aegypti mosquito, that also carries dengue, yellow fever and chikungunya viruses. This review will discuss the early virus-host interactions in dengue infection, with emphasis on the interrelationship between oxidative stress and innate immune pathways, and will provide insight as to how lessons learned from dengue research may expedite therapeutic strategies for Zika virus.
KW - Aedes/virology
KW - Animals
KW - Dengue Virus/immunology
KW - Host-Pathogen Interactions
KW - Humans
KW - Immunity, Innate
KW - Oxidative Stress
KW - Zika Virus/immunology
UR - http://www.scopus.com/inward/record.url?scp=84965053744&partnerID=8YFLogxK
U2 - 10.1016/j.jmb.2016.04.024
DO - 10.1016/j.jmb.2016.04.024
M3 - Review
C2 - 27130436
SN - 0022-2836
VL - 428
SP - 3429
EP - 3448
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
IS - 17
ER -