Delta and gamma oscillations in operculo-insular cortex underlie innocuous cold thermosensation

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Delta and gamma oscillations in operculo-insular cortex underlie innocuous cold thermosensation. / Fardo, Francesca; Vinding, Mikkel C.; Allen, Micah Galen et al.
In: Journal of Neurophysiology, Vol. 117, No. 5, 05.2017, p. 1959-1968.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Bibtex

@article{93861ea65f674a859b1dcf26f25cc478,

title = "Delta and gamma oscillations in operculo-insular cortex underlie innocuous cold thermosensation",

abstract = "Cold-sensitive and nociceptive neural pathways interact to shape the quality and intensity of thermal and pain perception. Yet, the central processing of cold-thermosensation in the human brain has not yet been extensively studied. Here, we used magnetoencephalography (MEG) and electroencephalography (EEG) in healthy volunteers, to investigate the time course (evoked fields and potentials) and oscillatory activity associated with the perception of cold temperature changes. Non-noxious cold stimuli consisting of Δ3°C and Δ5°C decrements from an adapting temperature of 35°C were delivered on the dorsum of the left hand via a contact thermode. Cold-evoked fields peaked at around 240 and 500 ms, at similar peak latencies as the N1 and P2 cold-evoked potentials. Importantly, cold-related changes in oscillatory power indicated that innocuous thermosensation is mediated by oscillatory activity in the range of delta (1-4 Hz) and gamma (55-90 Hz) rhythms, originating in operculo-insular cortical regions. We suggest that delta rhythms coordinate functional integration between operculo-insular and fronto-parietal regions, while gamma rhythms reflect local sensory processing in operculo-insular areas.",

keywords = "Journal Article",

author = "Francesca Fardo and Vinding, {Mikkel C.} and Allen, {Micah Galen} and Jensen, {Troels Staehelin} and Finnerup, {Nanna Brix}",

note = "Copyright {\textcopyright} 2016, Journal of Neurophysiology.",

year = "2017",

month = may,

doi = "10.1152/jn.00843.2016",

language = "English",

volume = "117",

pages = "1959--1968",

journal = "Journal of Neurophysiology",

issn = "0022-3077",

publisher = "American Physiological Society",

number = "5",

}

RIS

TY - JOUR

T1 - Delta and gamma oscillations in operculo-insular cortex underlie innocuous cold thermosensation

AU - Fardo, Francesca

AU - Vinding, Mikkel C.

AU - Allen, Micah Galen

AU - Jensen, Troels Staehelin

AU - Finnerup, Nanna Brix

PY - 2017/5

Y1 - 2017/5

N2 - Cold-sensitive and nociceptive neural pathways interact to shape the quality and intensity of thermal and pain perception. Yet, the central processing of cold-thermosensation in the human brain has not yet been extensively studied. Here, we used magnetoencephalography (MEG) and electroencephalography (EEG) in healthy volunteers, to investigate the time course (evoked fields and potentials) and oscillatory activity associated with the perception of cold temperature changes. Non-noxious cold stimuli consisting of Δ3°C and Δ5°C decrements from an adapting temperature of 35°C were delivered on the dorsum of the left hand via a contact thermode. Cold-evoked fields peaked at around 240 and 500 ms, at similar peak latencies as the N1 and P2 cold-evoked potentials. Importantly, cold-related changes in oscillatory power indicated that innocuous thermosensation is mediated by oscillatory activity in the range of delta (1-4 Hz) and gamma (55-90 Hz) rhythms, originating in operculo-insular cortical regions. We suggest that delta rhythms coordinate functional integration between operculo-insular and fronto-parietal regions, while gamma rhythms reflect local sensory processing in operculo-insular areas.

AB - Cold-sensitive and nociceptive neural pathways interact to shape the quality and intensity of thermal and pain perception. Yet, the central processing of cold-thermosensation in the human brain has not yet been extensively studied. Here, we used magnetoencephalography (MEG) and electroencephalography (EEG) in healthy volunteers, to investigate the time course (evoked fields and potentials) and oscillatory activity associated with the perception of cold temperature changes. Non-noxious cold stimuli consisting of Δ3°C and Δ5°C decrements from an adapting temperature of 35°C were delivered on the dorsum of the left hand via a contact thermode. Cold-evoked fields peaked at around 240 and 500 ms, at similar peak latencies as the N1 and P2 cold-evoked potentials. Importantly, cold-related changes in oscillatory power indicated that innocuous thermosensation is mediated by oscillatory activity in the range of delta (1-4 Hz) and gamma (55-90 Hz) rhythms, originating in operculo-insular cortical regions. We suggest that delta rhythms coordinate functional integration between operculo-insular and fronto-parietal regions, while gamma rhythms reflect local sensory processing in operculo-insular areas.

KW - Journal Article

U2 - 10.1152/jn.00843.2016

DO - 10.1152/jn.00843.2016

M3 - Journal article

C2 - 28250150

VL - 117

SP - 1959

EP - 1968

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 5

ER -

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