Definitions and Standardized Endpoints for Treatment of Coronary Bifurcations

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DOI

  • Mattia Lunardi, Department of Cardiology, Galway University Hospital, Galway, Ireland.
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  • Yves Louvard, Institut Cardiovasculaire Paris Sud
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  • Thierry Lefèvre, Institut Cardiovasculaire Paris Sud
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  • Goran Stankovic, University of Belgrade-School of Electrical Engineering
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  • Francesco Burzotta, Department of Cardiovascular Sciences, University of South Florida, Tampa, Florida.
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  • Ghassan S Kassab, California Medical Innovation Institute
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  • Jens Flensted Lassen, University of Southern Denmark
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  • Olivier Darremont, Clinique Saint-Augustin-Elsan
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  • Scot Garg, Royal Blackburn Hospital
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  • Bon-Kwon Koo, Seoul Natl Univ Hosp, Seoul National University, Seoul National University Hospital, Dept Surg
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  • Niels Ramsing Holm
  • Thomas W Johnson, Bristol Heart Institute, University Hospitals Bristol NHSFT, Bristol, UK.
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  • Manuel Pan, Hospital Universitario Reina Sofia
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  • Yiannis S Chatzizisis, Univ Nebraska, University of Nebraska System, University of Nebraska Medical Center, Med Ctr, Dept Pharmacol & Expt Neurosci
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  • Adrian P Banning, Oxford University Hospitals NHS Foundation Trust
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  • Alaide Chieffo, San Raffaele Hospital, Milan
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  • Dariusz Dudek, Second Department of Cardiology Jagiellonian University Medical College
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  • David Hildick-Smith, Department of Cardiology, CardioVascular Center Frankfurt, Frankfurt, Germany; Department of Cardiology, Swedish Medical Center, Seattle, Washington.
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  • Jérome Garot, Institut Cardiovasculaire Paris Sud
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  • Timothy D Henry, Carl and Edyth Lindner Center for Research and Education at the Christ Hospital
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  • George Dangas, The Zena and Michael A. Wiener Cardiovascular Institute, USA.
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  • Gregg Stone, The Zena and Michael A. Wiener Cardiovascular Institute, USA.
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  • Mitchell W Krucoff, From Guy's and St. Thomas' Hospitals, London (A.T.C.); the Department of Medicine, Stanford University, Stanford (R.A.H.), and Portola Pharmaceuticals, South San Francisco (B.L.W., A.G.) - both in California; the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School (S.Z.G.), and Beth Israel Deaconess Medical Center (C.M.G.) - both in Boston; the Faculty of Medicine, University of Calgary, Calgary, AB, Canada (R.D.H.); and the Division of Cardiology, Duke University and Duke Clinical Research Institute, Durham, NC (A.F.H.).
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  • Donald Cutlip, Harvard University
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  • Roxana Mehran, The Zena and Michael A. Wiener Cardiovascular Institute, USA.
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  • William Wijns, Department of Cardiology, Galway University Hospital, Galway, Ireland.
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  • Faisal Sharif, Department of Cardiology, Galway University Hospital, Galway, Ireland.
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  • Patrick W Serruys, Department of Cardiology, Galway University Hospital, Galway, Ireland.
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  • Yoshinobu Onuma, Department of Cardiology, Galway University Hospital, Galway, Ireland.

The Bifurcation Academic Research Consortium (Bif-ARC) project originated from the need to overcome the paucity of standardization and comparability between studies involving bifurcation coronary lesions. This document is the result of a collaborative effort between academic research organizations and the most renowned interventional cardiology societies focused on bifurcation lesions in Europe, the United States, and Asia. This consensus provides standardized definitions for bifurcation lesions; the criteria to judge the side branch relevance; the procedural, mechanistic, and clinical endpoints for every type of bifurcation study; and the follow-up methods. Considering the complexity of bifurcation lesions and their evaluation, detailed instructions and technical aspects for site and core laboratory analysis of bifurcation lesions are also reported. The recommendations included within this consensus will facilitate pooled analyses and the effective comparison of data in the future, improving the clinical relevance of trials in bifurcation lesions, and the quality of care in this subset of patients.

Original languageEnglish
JournalEuroIntervention
ISSN1774-024X
DOIs
Publication statusE-pub ahead of print - 18 May 2022

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